Timothy D. Fenn, Ph.D.

Affiliations: 
Brandeis University, Waltham, MA, United States 
Area:
relationship of protein three-dimensional structure to chemical function
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"Timothy Fenn"
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Dagmar Ringe grad student 2004 Brandeis
 (Enzymatic control of cofactor chemistry: Mechanisms of hydrogen ion transfer in alanine racemase and xylose isomerase.)
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Publications

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Avdic A, Tollefson MR, Tatro N, et al. (2017) Polarizable Amoeba Force Field Metadynamics with Minimization Predicts Missing Protein Loops Biophysical Journal. 112: 55a
LuCore SD, Litman JM, Powers KT, et al. (2015) Dead-End Elimination with a Polarizable Force Field Repacks PCNA Structures. Biophysical Journal. 109: 816-26
Andrews LD, Fenn TD, Herschlag D. (2013) Ground state destabilization by anionic nucleophiles contributes to the activity of phosphoryl transfer enzymes. Plos Biology. 11: e1001599
Vivona S, Cipriano DJ, O'Leary S, et al. (2013) Disassembly of all SNARE complexes by N-ethylmaleimide-sensitive factor (NSF) is initiated by a conserved 1:1 interaction between α-soluble NSF attachment protein (SNAP) and SNARE complex. The Journal of Biological Chemistry. 288: 24984-91
Sigala PA, Fafarman AT, Schwans JP, et al. (2013) Quantitative dissection of hydrogen bond-mediated proton transfer in the ketosteroid isomerase active site. Proceedings of the National Academy of Sciences of the United States of America. 110: E2552-61
Cipriano DJ, Jung J, Vivona S, et al. (2013) Processive ATP-driven substrate disassembly by the N-ethylmaleimide-sensitive factor (NSF) molecular machine. The Journal of Biological Chemistry. 288: 23436-45
Kaiser SE, Mao K, Taherbhoy AM, et al. (2012) Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7-Atg3 and Atg7-Atg10 structures. Nature Structural & Molecular Biology. 19: 1242-9
Fafarman AT, Sigala PA, Schwans JP, et al. (2012) Quantitative, directional measurement of electric field heterogeneity in the active site of ketosteroid isomerase. Proceedings of the National Academy of Sciences of the United States of America. 109: E299-308
Bobyr E, Lassila JK, Wiersma-Koch HI, et al. (2012) High-resolution analysis of Zn(2+) coordination in the alkaline phosphatase superfamily by EXAFS and x-ray crystallography. Journal of Molecular Biology. 415: 102-17
Fenn T, Schnieders M, Pande V. (2012) Bayesian Modeling of Crystallographic Disorder Biophysical Journal. 102: 225a
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