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Christopher B. Roth, Ph.D.

Affiliations: 
Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
Structural Biology, Receptors
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"Christopher Roth"
Mean distance: 8.18
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Parents

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Raymond C. Stevens grad student 2008 Scripps Institute
 (beta-adrenergic receptor stability engineering for the advancement of GPCR structural biology.)

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Publications

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Chrencik JE, Roth CB, Terakado M, et al. (2015) Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1. Cell. 161: 1633-43
Liu W, Chun E, Thompson AA, et al. (2012) Structural basis for allosteric regulation of GPCRs by sodium ions. Science (New York, N.Y.). 337: 232-6
Chun E, Thompson AA, Liu W, et al. (2012) Fusion partner toolchest for the stabilization and crystallization of G protein-coupled receptors. Structure (London, England : 1993). 20: 967-76
Hanson MA, Roth CB, Jo E, et al. (2012) Crystal structure of a lipid G protein-coupled receptor. Science (New York, N.Y.). 335: 851-5
Katritch V, Reynolds KA, Cherezov V, et al. (2009) Analysis of full and partial agonists binding to beta2-adrenergic receptor suggests a role of transmembrane helix V in agonist-specific conformational changes. Journal of Molecular Recognition : Jmr. 22: 307-18
Hanson MA, Cherezov V, Griffith MT, et al. (2008) A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor. Structure (London, England : 1993). 16: 897-905
Roth CB, Hanson MA, Stevens RC. (2008) Stabilization of the human beta2-adrenergic receptor TM4-TM3-TM5 helix interface by mutagenesis of Glu122(3.41), a critical residue in GPCR structure. Journal of Molecular Biology. 376: 1305-19
Ward A, Reyes CL, Yu J, et al. (2007) Flexibility in the ABC transporter MsbA: Alternating access with a twist. Proceedings of the National Academy of Sciences of the United States of America. 104: 19005-10
Hanson MA, Brooun A, Baker KA, et al. (2007) Profiling of membrane protein variants in a baculovirus system by coupling cell-surface detection with small-scale parallel expression. Protein Expression and Purification. 56: 85-92
Chang G, Roth CB. (2001) Structure of MsbA from E. coli: a homolog of the multidrug resistance ATP binding cassette (ABC) transporters. Science (New York, N.Y.). 293: 1793-800
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