Valerie A. Villareal, Ph.D.

Affiliations: 
University of California, Los Angeles, Los Angeles, CA 
Area:
molecular basis of bacterial pathogenesis
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"Valerie Villareal"
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Parents

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Robert T. Clubb grad student 2010 UCLA
 (Studies of Heme Acquisition by the Iron-Regulated Surface Determinant System in Staphylococcus aureus.)
Priscilla L. Yang post-doc Harvard Medical School
Priscilla L. Yang post-doc Harvard Medical School
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Publications

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Tallorin L, Villareal VA, Hsia CY, et al. (2020) Hepatitis C virus NS3-4A protease regulates the lipid environment for RNA replication by cleaving host enzyme 24-dehydrocholesterol reductase. The Journal of Biological Chemistry
Costello DA, Villareal VA, Yang PL. (2016) Desmosterol Increases Lipid Bilayer Fluidity during Hepatitis C Virus Infection. Acs Infectious Diseases. 2: 852-862
Villareal VA, Fu D, Costello DA, et al. (2016) Hepatitis C Virus Selectively Alters the Intracellular Localization of Desmosterol. Acs Chemical Biology
Villareal VA, Rodgers MA, Costello DA, et al. (2015) Targeting host lipid synthesis and metabolism to inhibit dengue and hepatitis C viruses. Antiviral Research
Carocci M, Hinshaw SM, Rodgers MA, et al. (2015) The bioactive lipid 4-hydroxyphenyl retinamide inhibits flavivirus replication. Antimicrobial Agents and Chemotherapy. 59: 85-95
Rodgers MA, Villareal VA, Schaefer EA, et al. (2012) Lipid metabolite profiling identifies desmosterol metabolism as a new antiviral target for hepatitis C virus. Journal of the American Chemical Society. 134: 6896-9
Yang PL, Gao M, Lin K, et al. (2011) Anti-HCV drugs in the pipeline. Current Opinion in Virology. 1: 607-16
Villareal VA, Spirig T, Robson SA, et al. (2011) Transient weak protein-protein complexes transfer heme across the cell wall of Staphylococcus aureus. Journal of the American Chemical Society. 133: 14176-9
Ramey JD, Villareal VA, Ng C, et al. (2010) Anthrax toxin receptor 1/tumor endothelial marker 8: mutation of conserved inserted domain residues overrides cytosolic control of protective antigen binding. Biochemistry. 49: 7403-10
Robson SA, Peterson R, Bouchard LS, et al. (2010) A heteronuclear zero quantum coherence Nz-exchange experiment that resolves resonance overlap and its application to measure the rates of heme binding to the IsdC protein. Journal of the American Chemical Society. 132: 9522-3
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