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Daniel L. Kaplan, Ph.D.

Affiliations: 
2000 Yale University, New Haven, CT 
Area:
Biochemistry, structural chemistry
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Thomas A. Steitz grad student 2000 Yale
 (Mechanistic studies of DnaB helicase.)

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Bruck I, Kaplan DL. (2017) The Dbf4-Cdc7 kinase promotes Mcm2-7 ring opening to allow for single-stranded DNA extrusion and helicase assembly. The Journal of Biological Chemistry. 292: 10320
Bruck I, Kaplan DL. (2017) Origin single-stranded DNA releases Sld3 protein from the Mcm2-7 complex, allowing the GINS tetramer to bind the Mcm2-7 complex. The Journal of Biological Chemistry. 292: 10318
Perez-Arnaiz P, Bruck I, Colbert MK, et al. (2017) An intact Mcm10 coiled-coil interaction surface is important for origin melting, helicase assembly and the recruitment of Pol-α to Mcm2-7. Nucleic Acids Research
Bruck I, Dhingra N, Martinez MP, et al. (2017) Dpb11 may function with RPA and DNA to initiate DNA replication. Plos One. 12: e0177147
Martinez MP, Wacker AL, Bruck I, et al. (2017) Eukaryotic Replicative Helicase Subunit Interaction with DNA and Its Role in DNA Replication. Genes. 8
Martinez MP, Jones JM, Bruck I, et al. (2017) Origin DNA Melting-An Essential Process with Divergent Mechanisms. Genes. 8
Bruck I, Dhingra N, Kaplan DL. (2017) A Positive-amplification Mechanism Involving a Kinase and Replication Initiation Factor Helps Assemble the Replication Fork Helicase. The Journal of Biological Chemistry
Perez-Arnaiz P, Kaplan DL. (2016) An Mcm10 mutant defective in ssDNA binding shows defects in DNA replication initiation. Journal of Molecular Biology
Bruck I, Perez-Arnaiz P, Colbert MK, et al. (2015) Insights into the Initiation of Eukaryotic DNA Replication. Nucleus (Austin, Tex.). 0
Perez-Arnaiz P, Bruck I, Kaplan DL. (2015) Mcm10 coordinates the timely assembly and activation of the replication fork helicase. Nucleic Acids Research
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