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Benjamin C. Li, Ph.D.

Affiliations: 
2013 Chemistry California Institute of Technology, Pasadena, CA 
Area:
DNA recognition
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"Benjamin Li"
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Peter B. Dervan grad student 2013 Caltech
 (Synthesis and Biological Studies of DNA-Binding Cyclic Py-Im Polyamides.)

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Publications

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Xu L, Wang W, Gotte D, et al. (2016) RNA polymerase II senses obstruction in the DNA minor groove via a conserved sensor motif. Proceedings of the National Academy of Sciences of the United States of America
Martínez TF, Phillips JW, Karanja KK, et al. (2014) Replication stress by Py-Im polyamides induces a non-canonical ATR-dependent checkpoint response. Nucleic Acids Research. 42: 11546-59
Yang F, Nickols NG, Li BC, et al. (2013) Animal toxicity of hairpin pyrrole-imidazole polyamides varies with the turn unit. Journal of Medicinal Chemistry. 56: 7449-57
Nickols NG, Szablowski JO, Hargrove AE, et al. (2013) Activity of a Py-Im polyamide targeted to the estrogen response element. Molecular Cancer Therapeutics. 12: 675-84
Yang F, Nickols NG, Li BC, et al. (2013) Antitumor activity of a pyrrole-imidazole polyamide. Proceedings of the National Academy of Sciences of the United States of America. 110: 1863-8
Li BC, Montgomery DC, Puckett JW, et al. (2013) Synthesis of cyclic Py-Im polyamide libraries. The Journal of Organic Chemistry. 78: 124-33
Nickols NG, Yang F, Li BC, et al. (2013) A second-generation DNA-binding pyrrole-imidazole polyamide with antitumor activity. Journal of Clinical Oncology. 31: e13588-e13588
Nickols NG, Yang F, Li BC, et al. (2013) Abstract 1130: Antitumor activity of a pyrrole-imidazole polyamide in three tumor xenograft models. Cancer Research. 73: 1130-1130
Nickols N, Yang F, Ratikan J, et al. (2013) Radiosensitization by High Affinity Programmable Minor Groove Binders International Journal of Radiation Oncology*Biology*Physics. 87: S651-S652
Synold TW, Xi B, Wu J, et al. (2012) Single-dose pharmacokinetic and toxicity analysis of pyrrole-imidazole polyamides in mice. Cancer Chemotherapy and Pharmacology. 70: 617-25
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