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Winston C. Tse, Ph.D.

Affiliations: 
2003 Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
synthetic organic chemistry
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"Winston Tse"
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Dale L. Boger grad student 2003 Scripps Institute
 (Exploring small molecule-DNA recognition through the use of a fluorescent intercalator displacement assay and structural analogues of bleomycin A(2).)

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Publications

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Lad L, Clancy S, Koditek D, et al. (2015) Functional label-free assays for characterizing the in vitro mechanism of action of small molecule modulators of capsid assembly. Biochemistry. 54: 2240-8
Tse WC, Boger DL. (2005) A fluorescent intercalator displacement assay for establishing DNA binding selectivity and affinity. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. Unit 8.5
Tse WC, Boger DL. (2004) Sequence-selective DNA recognition: natural products and nature's lessons. Chemistry & Biology. 11: 1607-17
Tse WC, Boger DL. (2004) A fluorescent intercalator displacement assay for establishing DNA binding selectivity and affinity. Accounts of Chemical Research. 37: 61-9
Ham YW, Tse WC, Boger DL. (2003) High-resolution assessment of protein DNA binding affinity and selectivity utilizing a fluorescent intercalator displacement (FID) assay. Bioorganic & Medicinal Chemistry Letters. 13: 3805-7
Yeung BK, Tse WC, Boger DL. (2003) Determination of binding affinities of triplex forming oligonucleotides using a fluorescent intercalator displacement (FID) assay. Bioorganic & Medicinal Chemistry Letters. 13: 3801-4
Tse WC, Ishii T, Boger DL. (2003) Comprehensive high-resolution analysis of hairpin polyamides utilizing a fluorescent intercalator displacement (FID) assay. Bioorganic & Medicinal Chemistry. 11: 4479-86
Boger DL, Tse WC. (2001) Thiazole orange as the fluorescent intercalator in a high resolution fid assay for determining DNA binding affinity and sequence selectivity of small molecules. Bioorganic & Medicinal Chemistry. 9: 2511-8
Boger DL, Ichikawa S, Tse WC, et al. (2001) Total syntheses of thiocoraline and BE-22179 and assessment of their DNA binding and biological properties. Journal of the American Chemical Society. 123: 561-8
Boger DL, Fink BE, Brunette SR, et al. (2001) A simple, high-resolution method for establishing DNA binding affinity and sequence selectivity. Journal of the American Chemical Society. 123: 5878-91
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