John D. Trzupek, Ph.D.
Affiliations: | 2006 | Scripps Research Institute, La Jolla, La Jolla, CA, United States |
Area:
synthetic organic chemistryGoogle:
"John Trzupek"Mean distance: 8.34
Parents
Sign in to add mentor| Dale L. Boger | grad student | 2006 | Scripps Institute | |
| (Part I: Efficient synthesis of the DEF ring system of complestatin. Part II: Alkylation properties of (+)- and ent-(-)-yatakemycin in protein-free DNA and in nucleosome core particles.) | ||||
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Publications
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| Lee KL, Ambler CM, Anderson DR, et al. (2017) Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design. Journal of Medicinal Chemistry |
| Knochel P, Hammann JM, Wright SW, et al. (2016) Reverse Diastereocontrol in the Conjugate Addition of Cuprates Synfacts. 12: 80-80 |
| Wright SW, Choi C, Chung S, et al. (2015) Reversal of Diastereoselection in the Conjugate Addition of Cuprates to Unsaturated Lactams. Organic Letters |
| Trzupek JD, Li C, Chan C, et al. (2010) Lessons from the Total Synthesis of (±) Phalarine: Insights Into the Mechanism of the Pictet-Spengler Reaction. Pure and Applied Chemistry. Chimie Pure Et Appliquee. 82: 1735-1748 |
| Trzupek JD, Lee D, Crowley BM, et al. (2010) Total synthesis of enantiopure phalarine via a stereospecific Pictet-Spengler reaction: traceless transfer of chirality from L-tryptophan. Journal of the American Chemical Society. 132: 8506-12 |
| Shimamura H, Breazzano SP, Garfunkle J, et al. (2010) Total synthesis of complestatin: development of a Pd(0)-mediated indole annulation for macrocyclization. Journal of the American Chemical Society. 132: 7776-83 |
| Trzupek JD, Li C, Chan C, et al. (2010) Lessons from the total synthesis of (±)-phalarine: Insights into the mechanism of the Pictet-Spengler reaction Pure and Applied Chemistry. 82: 1735-1748 |
| Danishefsky S, Trzupek J, Lee D, et al. (2010) Synthesis of (-)-Phalarine Synfacts. 2010: 1099-1099 |
| Garfunkle J, Kimball FS, Trzupek JD, et al. (2010) Synthesis of Chloropeptin II Synfacts. 2010: 263-263 |
| Garfunkle J, Kimball FS, Trzupek JD, et al. (2009) Total synthesis of chloropeptin II (complestatin) and chloropeptin I. Journal of the American Chemical Society. 131: 16036-8 |