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Wu Du, Ph.D.

Affiliations: 
2002 University of Pittsburgh, Pittsburgh, PA, United States 
Area:
radical chemistry
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"Wu Du"
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Dennis P. Curran grad student 2002 University of Pittsburgh
 (Cascade radical cyclization: Application in the development of new anticancer drug of camptothecin family and development of new synthetic method.)

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Publications

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Du K, Luo Z, Guo P, et al. (2015) Preparation and evaluation of a molecularly imprinted sol-gel material as the solid-phase extraction adsorbents for the specific recognition of cloxacilloic acid in cloxacillin. Journal of Separation Science
Zhan G, Shi ML, He Q, et al. (2015) [4 + 3] Cycloadditions with Bromo-Substituted Morita-Baylis-Hillman Adducts of Isatins and N-(ortho-Chloromethyl)aryl Amides. Organic Letters
Laco GS, Du W, Kohlhagen G, et al. (2004) Analysis of human topoisomerase I inhibition and interaction with the cleavage site +1 deoxyguanosine, via in vitro experiments and molecular modeling studies. Bioorganic & Medicinal Chemistry. 12: 5225-35
Du W, Curran DP. (2003) Synthesis of carbocyclic and heterocyclic fused quinolines by cascade radical annulations of unsaturated N-aryl thiocarbamates, thioamides, and thioureas. Organic Letters. 5: 1765-8
Du W, Kaskar B, Blumbergs P, et al. (2003) Semisynthesis of DB-67 and other silatecans from camptothecin by thiol-promoted addition of silyl radicals. Bioorganic & Medicinal Chemistry. 11: 451-8
Shibasaki M, Yabu K, Masumoto S, et al. (2003) Catalytic Enantioselective Synthesis of (20S)-Camptothecin Intermediates Using Cyanosilylation of Ketones Promoted by D-Glucose-derived Lanthanide Catalyst Heterocycles. 59: 369
Du W, Curran DP. (2003) Cascade 4+1 radical annulations of 2,6-disubstituted phenyl isonitriles with N-propargyl-6-iodopyridones: Scope, mechanism and regioselective synthesis of 7,9-disubstituted camptothecin analogs Synlett. 1299-1302
Curran DP, Du W. (2002) Palladium-promoted cascade reactions of isonitriles and 6-iodo-N-propargylpyridones: synthesis of mappicines, camptothecins, and homocamptothecins. Organic Letters. 4: 3215-8
Liu X, Lynn BC, Zhang J, et al. (2002) A versatile prodrug approach for liposomal core-loading of water-insoluble camptothecin anticancer drugs. Journal of the American Chemical Society. 124: 7650-1
Du W, Curran DP, Bevins RL, et al. (2002) Synthesis and evaluation of a novel E-ring modified alpha-hydroxy keto ether analogue of camptothecin. Bioorganic & Medicinal Chemistry. 10: 103-10
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