Ariele P. Hanek, Ph.D.

Affiliations: 
2009 Chemistry California Institute of Technology, Pasadena, CA 
Area:
physical organic chemistry to systems of biological importance
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"Ariele Hanek"
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Parents

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Dennis A. Dougherty grad student 2009 Caltech
 (Chemical-Scale Investigations of Cys-Loop Neurotransmitter Gated Ion Channels.)
Christopher Noren post-doc 2009-2012 New England Biolabs
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Publications

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Pless SA, Hanek AP, Price KL, et al. (2011) A cation-π interaction at a phenylalanine residue in the glycine receptor binding site is conserved for different agonists. Molecular Pharmacology. 79: 742-8
Hanek AP, Lester HA, Dougherty DA. (2010) Photochemical proteolysis of an unstructured linker of the GABAAR extracellular domain prevents GABA but not pentobarbital activation. Molecular Pharmacology. 78: 29-35
Pless SA, Millen KS, Hanek AP, et al. (2008) A cation-pi interaction in the binding site of the glycine receptor is mediated by a phenylalanine residue. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 10937-42
Hanek AP, Lester HA, Dougherty DA. (2008) A stereochemical test of a proposed structural feature of the nicotinic acetylcholine receptor. Journal of the American Chemical Society. 130: 13216-8
Padgett CL, Hanek AP, Lester HA, et al. (2007) Unnatural amino acid mutagenesis of the GABA(A) receptor binding site residues reveals a novel cation-pi interaction between GABA and beta 2Tyr97. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 886-92
Xiu X, Hanek AP, Wang J, et al. (2005) A unified view of the role of electrostatic interactions in modulating the gating of Cys loop receptors. The Journal of Biological Chemistry. 280: 41655-66
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