Jacob S. Appelbaum, Ph.D.

Affiliations: 
2012 Cell Biology Yale University, New Haven, CT 
Area:
protein–protein and protein–DNA interactions
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"Jacob Appelbaum"
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Alanna Schepartz grad student 2012 Yale
 (Discrete arginine topologies guide escape of miniature proteins from early endosomes to the cytoplasm.)
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Publications

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Holub JM, Larochelle JR, Appelbaum JS, et al. (2013) Improved assays for determining the cytosolic access of peptides, proteins, and their mimetics. Biochemistry. 52: 9036-46
Denton EV, Craig CJ, Pongratz RL, et al. (2013) A β-peptide agonist of the GLP-1 receptor, a class B GPCR. Organic Letters. 15: 5318-21
Appelbaum JS, LaRochelle JR, Smith BA, et al. (2012) Arginine topology controls escape of minimally cationic proteins from early endosomes to the cytoplasm. Chemistry & Biology. 19: 819-30
Scheck RA, Lowder MA, Appelbaum JS, et al. (2012) Bipartite tetracysteine display reveals allosteric control of ligand-specific EGFR activation. Acs Chemical Biology. 7: 1367-76
Lowder MA, Appelbaum JS, Hobert EM, et al. (2011) Visualizing protein partnerships in living cells and organisms. Current Opinion in Chemical Biology. 15: 781-8
Bautista AD, Appelbaum JS, Craig CJ, et al. (2010) Bridged beta(3)-peptide inhibitors of p53-hDM2 complexation: correlation between affinity and cell permeability. Journal of the American Chemical Society. 132: 2904-6
Halo TL, Appelbaum J, Hobert EM, et al. (2009) Selective recognition of protein tetraserine motifs with a cell-permeable, pro-fluorescent bis-boronic acid. Journal of the American Chemical Society. 131: 438-9
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