Catherine E. Leimkuhler, Ph.D.
Affiliations: | 2006 | Harvard University, Cambridge, MA, United States |
Area:
molecular mechanisms of various antibioticsGoogle:
"Catherine Leimkuhler"Mean distance: 8.43 | S | N | B | C | P |
Parents
Sign in to add mentor| Daniel E. Kahne | grad student | 2006 | Harvard | |
| (Synthesis and evaluation of glycopeptide antibiotics that overcome resistance.) | ||||
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Publications
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| Leimkuhler C, Fridman M, Lupoli T, et al. (2007) Characterization of rhodosaminyl transfer by the AknS/AknT glycosylation complex and its use in reconstituting the biosynthetic pathway of aclacinomycin A. Journal of the American Chemical Society. 129: 10546-50 |
| Howard-Jones AR, Kruger RG, Lu W, et al. (2007) Kinetic analysis of teicoplanin glycosyltransferases and acyltransferase reveal ordered tailoring of aglycone scaffold to reconstitute mature teicoplanin. Journal of the American Chemical Society. 129: 10082-3 |
| Adachi M, Zhang Y, Leimkuhler C, et al. (2006) Degradation and reconstruction of moenomycin A and derivatives: dissecting the function of the isoprenoid chain. Journal of the American Chemical Society. 128: 14012-3 |
| Yuan Y, Chung HS, Leimkuhler C, et al. (2005) In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides. Journal of the American Chemical Society. 127: 14128-9 |
| Oberthür M, Leimkuhler C, Kruger RG, et al. (2005) A systematic investigation of the synthetic utility of glycopeptide glycosyltransferases. Journal of the American Chemical Society. 127: 10747-52 |
| Lu W, Leimkuhler C, Gatto GJ, et al. (2005) AknT is an activating protein for the glycosyltransferase AknS in L-aminodeoxysugar transfer to the aglycone of aclacinomycin A. Chemistry & Biology. 12: 527-34 |
| Leimkuhler C, Chen L, Barrett D, et al. (2005) Differential inhibition of Staphylococcus aureus PBP2 by glycopeptide antibiotics. Journal of the American Chemical Society. 127: 3250-1 |
| Barrett D, Leimkuhler C, Chen L, et al. (2005) Kinetic characterization of the glycosyltransferase module of Staphylococcus aureus PBP2. Journal of Bacteriology. 187: 2215-7 |
| Kahne D, Leimkuhler C, Lu W, et al. (2005) Glycopeptide and lipoglycopeptide antibiotics Chemical Reviews. 105: 425-448 |
| Leimkuhler C, Chen Z, Kruger RG, et al. (2005) Glycosylation of glycopeptides: A comparison of chemoenzymatic and chemical methods Tetrahedron Asymmetry. 16: 599-603 |