Emma H. Doud, Ph.D.

Affiliations: 
2011 Harvard University, Cambridge, MA, United States 
Area:
molecular mechanisms of various antibiotics
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Daniel E. Kahne grad student 2011 Harvard
 (The genetics and biochemistry of moenomycin biosynthesis.)
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Makitrynskyy R, Ostash B, Tsypik O, et al. (2013) Pleiotropic regulatory genes bldA, adpA and absB are implicated in production of phosphoglycolipid antibiotic moenomycin. Open Biology. 3: 130121
Gampe CM, Tsukamoto H, Doud EH, et al. (2013) Tuning the moenomycin pharmacophore to enable discovery of bacterial cell wall synthesis inhibitors. Journal of the American Chemical Society. 135: 3776-9
Lupoli TJ, Tsukamoto H, Doud EH, et al. (2011) Transpeptidase-mediated incorporation of D-amino acids into bacterial peptidoglycan. Journal of the American Chemical Society. 133: 10748-51
Doud EH, Perlstein DL, Wolpert M, et al. (2011) Two distinct mechanisms for TIM barrel prenyltransferases in bacteria. Journal of the American Chemical Society. 133: 1270-3
Ostash B, Doud E, Fedorenko V. (2010) The molecular biology of moenomycins: towards novel antibiotics based on inhibition of bacterial peptidoglycan glycosyltransferases. Biological Chemistry. 391: 499-504
Perlstein DL, Wang TS, Doud EH, et al. (2010) The role of the substrate lipid in processive glycan polymerization by the peptidoglycan glycosyltransferases. Journal of the American Chemical Society. 132: 48-9
Ostash B, Doud EH, Lin C, et al. (2009) Complete characterization of the seventeen step moenomycin biosynthetic pathway. Biochemistry. 48: 8830-41
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