Justin T. Ernst, Ph.D.
Affiliations: | 2002 | Yale University, New Haven, CT |
Area:
chemical biologyGoogle:
"Justin Ernst"Mean distance: 8.23 | S | N | B | C | P |
Parents
Sign in to add mentor| Andrew D. Hamilton | grad student | 2002 | Yale | |
| (The design of small molecule antagonists of protein -protein interactions based on alpha -helix mimicry.) | ||||
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Publications
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| Montalban AG, Boman E, Chang CD, et al. (2010) Optimization of alpha-ketoamide based p38 inhibitors through modifications to the region that binds to the allosteric site. Bioorganic & Medicinal Chemistry Letters. 20: 4819-24 |
| Montalban AG, Boman E, Chang CD, et al. (2010) KR-003048, a potent, orally active inhibitor of p38 mitogen-activated protein kinase. European Journal of Pharmacology. 632: 93-102 |
| Montalban AG, Boman E, Chang CD, et al. (2008) The design and synthesis of novel alpha-ketoamide-based p38 MAP kinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 1772-7 |
| Yin H, Lee GI, Sedey KA, et al. (2005) Terphenyl-Based Bak BH3 alpha-helical proteomimetics as low-molecular-weight antagonists of Bcl-xL. Journal of the American Chemical Society. 127: 10191-6 |
| Jain R, Ernst JT, Kutzki O, et al. (2004) Protein recognition using synthetic surface-targeted agents. Molecular Diversity. 8: 89-100 |
| Ernst JT, Becerril J, Park HS, et al. (2003) Design and application of an alpha-helix-mimetic scaffold based on an oligoamide-foldamer strategy: antagonism of the Bak BH3/Bcl-xL complex. Angewandte Chemie (International Ed. in English). 42: 535-9 |
| Ernst JT, Kutzki O, Debnath AK, et al. (2002) Design of a protein surface antagonist based on alpha-helix mimicry: inhibition of gp41 assembly and viral fusion. Angewandte Chemie (International Ed. in English). 41: 278-81 |
| Zhao Q, Ernst JT, Hamilton AD, et al. (2002) XTT formazan widely used to detect cell viability inhibits HIV type 1 infection in vitro by targeting gp41. Aids Research and Human Retroviruses. 18: 989-97 |
| Kutzki O, Park HS, Ernst JT, et al. (2002) Development of a potent Bcl-x(L) antagonist based on alpha-helix mimicry. Journal of the American Chemical Society. 124: 11838-9 |
| Orner BP, Ernst JT, Hamilton AD. (2001) Toward proteomimetics: terphenyl derivatives as structural and functional mimics of extended regions of an alpha-helix. Journal of the American Chemical Society. 123: 5382-3 |