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Christopher G. Cummings, Ph.D.

Affiliations: 
2009 Yale University, New Haven, CT 
Area:
chemical biology
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"Christopher Cummings"
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Andrew D. Hamilton grad student 2009 Yale
 (Small molecule mimicry towards disrupting biologically relevant systems.)

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Publications

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Sebti SM, Kazi A, Xiang S, et al. (2019) Dual farnesyl and geranylgeranyl transferase inhibitor thwarts mutant KRAS-driven patient-derived pancreatic tumors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research
Kazi A, Xiang S, Yang H, et al. (2019) Abstract 3088: Farnesyl/geranylgeranyl transferase dual inhibitor thwarts mutant KRas-driven patient-derived pancreatic tumors Cancer Research
Aslamuzzaman K, Zhang X, Luo Y, et al. (2014) Abstract B35: Dual inhibitors of FT and GGT-1 as novel therapeutic agents for K-Ras-dependent tumors Molecular Cancer Research. 12
Zhang W, Zhang D, Stashko MA, et al. (2014) Correction to Pseudo-Cyclization through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines as New Mer Kinase Inhibitors Journal of Medicinal Chemistry. 57: 7141-7141
Zhang W, Zhang D, Stashko MA, et al. (2013) Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. Journal of Medicinal Chemistry. 56: 9683-92
Cummings CG, Hamilton AD. (2013) Expedient route to functionalized and water soluble 5-6-5 imidazole-phenyl-thiazole based α-helix mimetics Tetrahedron. 69: 1663-1668
Kazi A, Luo Y, Berndt N, et al. (2011) Abstract 620: Development of a dual protein farnesyltransferase -geranylgeranyltransferase-I inhibitor with antitumor activity against human cancer cells Cancer Research. 71: 620-620
Fletcher S, Keaney EP, Cummings CG, et al. (2010) Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents. Journal of Medicinal Chemistry. 53: 6867-88
Cummings CG, Hamilton AD. (2010) Disrupting protein-protein interactions with non-peptidic, small molecule alpha-helix mimetics. Current Opinion in Chemical Biology. 14: 341-6
Hast MA, Fletcher S, Cummings CG, et al. (2009) Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase. Chemistry & Biology. 16: 181-92
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