Patrick J. O'Brien, Ph.D.

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McNally JR, Ames AM, Admiraal SJ, et al. (2023) Human DNA ligases I and III have stand-alone end-joining capability, but differ in ligation efficiency and specificity. Nucleic Acids Research. 51: 796-805
Jurkiw TJ, Tumbale PP, Schellenberg MJ, et al. (2021) LIG1 syndrome mutations remodel a cooperative network of ligand binding interactions to compromise ligation efficiency. Nucleic Acids Research
Baldwin MR, Admiraal SJ, O'Brien PJ. (2020) Transient kinetic analysis of oxidative dealkylation by the direct reversal DNA repair enzyme AlkB. The Journal of Biological Chemistry
Thelen AZ, O'Brien PJ. (2019) Recognition of 1,-ethenoguanine by alkyladenine DNA glycosylase is restricted by a conserved active site residue. The Journal of Biological Chemistry
Tumbale PP, Jurkiw TJ, Schellenberg MJ, et al. (2019) Two-tiered enforcement of high-fidelity DNA ligation. Nature Communications. 10: 5431
Admiraal SJ, Eyler DE, Baldwin MR, et al. (2019) Expansion of base excision repair compensates for a lack of DNA repair by oxidative dealkylation in budding yeast. The Journal of Biological Chemistry
Taylor EL, Kesavan PM, Wolfe AE, et al. (2018) Distinguishing Specific and Nonspecific Complexes of Alkyladenine DNA Glycosylase. Biochemistry
McNally JR, O'Brien PJ. (2017) Kinetic Analyses of Single-Strand Break Repair by Human DNA Ligase III Isoforms Reveals Biochemical Differences from DNA Ligase I. The Journal of Biological Chemistry
Hendershot JM, O'Brien PJ. (2017) Search for DNA Damage by Human Alkyladenine DNA Glycosylase Involves Early Intercalation by an Aromatic Residue. The Journal of Biological Chemistry
Hendershot JM, O'Brien PJ. (2017) Transient Kinetic Methods for Mechanistic Characterization of DNA Binding and Nucleotide Flipping. Methods in Enzymology. 592: 377-415