Andrew S. Rosenthal, Ph.D.
Affiliations: | 2010 | Johns Hopkins University, Baltimore, MD |
Area:
Medicinal, Organic and Organometallic ChemistryGoogle:
"Andrew Rosenthal"Mean distance: 8.28 | S | N | B | C | P |
Parents
Sign in to add mentor| Gary Herbert Posner | grad student | 2010 | Johns Hopkins | |
| (Design and synthesis of novel antimalarial and anticancer artemisinin-derived trioxanes and thiol -olefin co -oxygenation (toco)-derived endoperoxides.) | ||||
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Publications
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| Dexheimer TS, Rosenthal AS, Luci DK, et al. (2014) Synthesis and structure-activity relationship studies of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against nonsmall cell lung cancer. Journal of Medicinal Chemistry. 57: 8099-110 |
| Marchand C, Huang SY, Dexheimer TS, et al. (2014) Biochemical assays for the discovery of TDP1 inhibitors. Molecular Cancer Therapeutics. 13: 2116-26 |
| Dexheimer TS, Rosenthal AS, Luci D, et al. (2014) Abstract LB-11: Discovery, synthesis, and structure-activity relationship of N-benzyl-2-phenylpyrimidin-4-amine derivatives as potent USP1/UAF1 deubiquitinase inhibitors with anticancer activity against non-small cell lung cancer Cancer Research. 74 |
| Rosenthal AS, Dexheimer TS, Gileadi O, et al. (2013) Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase. Bioorganic & Medicinal Chemistry Letters. 23: 5660-6 |
| Nguyen GH, Dexheimer TS, Rosenthal AS, et al. (2013) A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells. Chemistry & Biology. 20: 55-62 |
| He R, Mott BT, Rosenthal AS, et al. (2011) An artemisinin-derived dimer has highly potent anti-cytomegalovirus (CMV) and anti-cancer activities Plos One. 6 |
| Rosenthal AS, Tanega C, Shen M, et al. (2011) Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk). Bioorganic & Medicinal Chemistry Letters. 21: 3152-8 |
| Arav-Boger R, He R, Chiou CJ, et al. (2010) Artemisinin-derived dimers have greatly improved anti-cytomegalovirus activity compared to artemisinin monomers Plos One. 5 |
| Rosenthal AS, Chen X, Liu JO, et al. (2009) Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells. Journal of Medicinal Chemistry. 52: 1198-203 |
| Hartwig CL, Rosenthal AS, D'Angelo J, et al. (2009) Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent Biochemical Pharmacology. 77: 322-336 |