Heidi J. Imker, Ph.D.

Affiliations: 
2008 University of Illinois, Urbana-Champaign, Urbana-Champaign, IL 
Area:
structure/function relationships for enzyme-catalyzed reactions
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"Heidi Imker"
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John A. Gerlt grad student 2008 UIUC
 (Assignment of enzyme function through characterization of the RuBisCO and enolase superfamilies.)
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Publications

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Gerlt JA, Bouvier JT, Davidson DB, et al. (2015) Enzyme Function Initiative-Enzyme Similarity Tool (EFI-EST): A web tool for generating protein sequence similarity networks. Biochimica Et Biophysica Acta. 1854: 1019-1037
Warlick BPE, Imker HJ, Sriram J, et al. (2012) Mechanistic diversity in the RuBisCO superfamily: RuBisCO from rhodospirillum rubrum is not promiscuous for reactions catalyzed by RuBisCO-like proteins Biochemistry. 51: 9470-9479
Erb TJ, Evans BS, Cho K, et al. (2012) A RubisCO-like protein links SAM metabolism with isoprenoid biosynthesis. Nature Chemical Biology. 8: 926-32
Warlick BP, Evans BS, Erb TJ, et al. (2012) 1-methylthio-d-xylulose 5-phosphate methylsulfurylase: A novel route to 1-deoxy-d-xylulose 5-phosphate in Rhodospirillum rubrum Biochemistry. 51: 8324-8326
Lukk T, Sakai A, Kalyanaraman C, et al. (2012) Homology models guide discovery of diverse enzyme specificities among dipeptide epimerases in the enolase superfamily. Proceedings of the National Academy of Sciences of the United States of America. 109: 4122-7
Gerlt JA, Allen KN, Almo SC, et al. (2011) The Enzyme Function Initiative. Biochemistry. 50: 9950-62
Imker HJ, Krahn D, Clerc J, et al. (2010) N-acylation during glidobactin biosynthesis by the tridomain nonribosomal peptide synthetase module GlbF. Chemistry & Biology. 17: 1077-83
Zhang W, Heemstra JR, Walsh CT, et al. (2010) Activation of the pacidamycin PacL adenylation domain by MbtH-like proteins. Biochemistry. 49: 9946-7
Imker HJ, Walsh CT, Wuest WM. (2009) SylC catalyzes ureido-bond formation during biosynthesis of the proteasome inhibitor syringolin A. Journal of the American Chemical Society. 131: 18263-5
Chan KK, Wood BM, Fedorov AA, et al. (2009) Mechanism of the orotidine 5′-monophosphate decarboxylase-catalyzed reaction: Evidence for substrate destabilization Biochemistry. 48: 5518-5531
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