Patrick J. Lupardus, Ph.D.
Affiliations: | 2005 | Stanford University, Palo Alto, CA |
Area:
DNA damage responseGoogle:
"Patrick Lupardus"Mean distance: 8.06 | S | N | B | C | P |
Parents
Sign in to add mentor| Karlene A. Cimprich | grad student | 2005 | Stanford | |
| (The roles of DNA replication and the Rad1/Hus1/Rad9 complex in activation of the ATR-mediated DNA damage checkpoint.) | ||||
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Publications
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| Rajapaksa NS, Gobbi A, Drobnick J, et al. (2020) Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity. Acs Medicinal Chemistry Letters. 11: 327-333 |
| Hamilton GL, Chen H, Deshmukh G, et al. (2019) Potent and selective inhibitors of receptor-interacting protein kinase 1 that lack an aromatic back pocket group. Bioorganic & Medicinal Chemistry Letters |
| Patel S, Webster JD, Varfolomeev E, et al. (2019) RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases. Cell Death & Differentiation. 27: 161-175 |
| Ferrao RD, Wallweber HJ, Lupardus PJ. (2018) Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation. Elife. 7 |
| Ferrao RD, Wallweber HJ, Lupardus PJ. (2018) Author response: Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation Elife |
| Ferrao R, Lupardus PJ. (2017) The Janus Kinase (JAK) FERM and SH2 Domains: Bringing Specificity to JAK-Receptor Interactions. Frontiers in Endocrinology. 8: 71 |
| Ferrao R, Wallweber HJ, Ho H, et al. (2016) The Structural Basis for Class II Cytokine Receptor Recognition by JAK1. Structure (London, England : 1993) |
| Lupardus PJ, Ultsch M, Wallweber H, et al. (2014) Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition. Proceedings of the National Academy of Sciences of the United States of America. 111: 8025-30 |
| Wallweber HJ, Tam C, Franke Y, et al. (2014) Structural basis of recognition of interferon-α receptor by tyrosine kinase 2. Nature Structural & Molecular Biology. 21: 443-8 |
| Wallweber HJA, Tam C, Franke Y, et al. (2014) Structural basis of IFN receptor recognition by TYK2 Nature Structural & Molecular Biology. 21: 443 |