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Lewyn Li, Ph.D.

Affiliations: 
2002 Harvard University, Cambridge, MA, United States 
Area:
Protein Folding and Design, Molecular Evolution, Drug Discovery
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"Lewyn Li"
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Eugene I. Shakhnovich grad student 2002 Harvard
 (Protein folding and dynamics: Computer simulation, experiment and theory.)

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Publications

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Lin X, Spindler TJ, Fonseca MAdS, et al. (2020) Abstract A30: Super-enhancer-associated long noncoding RNA UCA1 interacts directly with AMOT to inhibit Hippo signaling pathway in epithelial ovarian cancer Molecular Cancer Research. 18
Lin X, Spindler TJ, de Souza Fonseca MA, et al. (2019) Super-Enhancer-Associated LncRNA UCA1 Interacts Directly with AMOT to Activate YAP Target Genes in Epithelial Ovarian Cancer. Iscience. 17: 242-255
Cato L, de Tribolet-Hardy J, Lee I, et al. (2019) ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer. Cancer Cell
Cejas P, Mullane SA, Duarte M, et al. (2016) Fixed tissue ChIP-seq (FiT-Seq) of archived FFPE clinical bladder cancer (BC) samples to reveal tumor-specific enhancer and super-enhancer profiles. Journal of Clinical Oncology. 34: 4541-4541
Su Y, Subedee A, Bloushtain-Qimron N, et al. (2015) Somatic Cell Fusions Reveal Extensive Heterogeneity in Basal-like Breast Cancer. Cell Reports. 11: 1549-63
Li L, Shakhnovich EI, Mirny LA. (2003) Amino acids determining enzyme-substrate specificity in prokaryotic and eukaryotic protein kinases. Proceedings of the National Academy of Sciences of the United States of America. 100: 4463-8
Dokholyan NV, Li L, Ding F, et al. (2002) Topological determinants of protein folding. Proceedings of the National Academy of Sciences of the United States of America. 99: 8637-41
Li L, Shakhnovich EI. (2001) Constructing, verifying, and dissecting the folding transition state of chymotrypsin inhibitor 2 with all-atom simulations. Proceedings of the National Academy of Sciences of the United States of America. 98: 13014-8
Li L, Shakhnovich EI. (2001) Different circular permutations produced different folding nuclei in proteins: a computational study. Journal of Molecular Biology. 306: 121-32
Choe SE, Li L, Matsudaira PT, et al. (2000) Differential stabilization of two hydrophobic cores in the transition state of the villin 14T folding reaction. Journal of Molecular Biology. 304: 99-115
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