Jana A. Lewis, Ph.D.

Affiliations: 
2007 University of California, San Diego, La Jolla, CA 
Area:
Bioinorganic and coordination chemistry. Metalloprotein inhibitors and supramolecular materials
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"Jana Lewis"
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Seth M. Cohen grad student 2007 UCSD
 (Heterocyclic metal -binding groups for matrix metalloproteinase and anthrax lethal factor inhibition.)
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Publications

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Jacobsen FE, Lewis JA, Cohen SM. (2007) The design of inhibitors for medicinally relevant metalloproteins. Chemmedchem. 2: 152-71
Jacobsen FE, Lewis JA, Heroux KJ, et al. (2007) Characterization and evaluation of pyrone and tropolone chelators for use in metalloprotein inhibitors Inorganica Chimica Acta. 360: 264-272
Lewis JA, Mongan J, McCammon JA, et al. (2006) Evaluation and binding-mode prediction of thiopyrone-based inhibitors of anthrax lethal factor. Chemmedchem. 1: 694-7
Jacobsen FE, Lewis JA, Cohen SM. (2006) A new role for old ligands: discerning chelators for zinc metalloproteinases. Journal of the American Chemical Society. 128: 3156-7
Puerta DT, Griffin MO, Lewis JA, et al. (2006) Heterocyclic zinc-binding groups for use in next-generation matrix metalloproteinase inhibitors: potency, toxicity, and reactivity. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 11: 131-8
Romero-Perez D, Puerta D, Lewis J, et al. (2006) A34. Development of novel matrix metalloproteinase inhibitors and their effects on isolated stunned hearts Journal of Molecular and Cellular Cardiology. 40: 896
Lewis JA, Tran BL, Puerta DT, et al. (2005) Synthesis, structure and spectroscopy of new thiopyrone and hydroxypyridinethione transition-metal complexes. Dalton Transactions (Cambridge, England : 2003). 2588-96
Lewis JA, Cohen SM. (2004) Addressing lead toxicity: complexation of lead(II) with thiopyrone and hydroxypyridinethione O,S mixed chelators. Inorganic Chemistry. 43: 6534-6
Puerta DT, Lewis JA, Cohen SM. (2004) New beginnings for matrix metalloproteinase inhibitors: identification of high-affinity zinc-binding groups. Journal of the American Chemical Society. 126: 8388-9
Lewis JA, Puerta DT, Cohen SM. (2003) Metal complexes of the trans-influencing ligand thiomaltol. Inorganic Chemistry. 42: 7455-9
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