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Douglas R. Davies, Ph.D.

Affiliations: 
2000 University of Wisconsin, Madison, Madison, WI 
Area:
Structural Biology
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"Douglas Davies"
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Ivan Rayment grad student 2000 UW Madison
 (Structural studies of Tn5 transposase.)

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Publications

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Rai G, Urban DJ, Mott BT, et al. (2020) Pyrazole-Based Lactate Dehydrogenase (LDH) Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties. Journal of Medicinal Chemistry
Dumais M, Davies DR, Lin T, et al. (2018) Structure and analysis of nucleoside diphosphate kinase from Borrelia burgdorferi prepared in a transition-state complex with ADP and vanadate moieties. Acta Crystallographica. Section F, Structural Biology Communications. 74: 373-384
Rai G, Brimacombe KR, Mott BT, et al. (2017) Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). Journal of Medicinal Chemistry
Ojo KK, Ranade RM, Zhang Z, et al. (2016) Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis. Plos One. 11: e0160350
Gelinas AD, Davies DR, Janjic N. (2016) Embracing proteins: structural themes in aptamer-protein complexes. Current Opinion in Structural Biology. 36: 122-132
Jarvis TC, Davies DR, Hisaminato A, et al. (2015) Non-helical DNA Triplex Forms a Unique Aptamer Scaffold for High Affinity Recognition of Nerve Growth Factor. Structure (London, England : 1993). 23: 1293-304
Phan IQ, Davies DR, Moretti NS, et al. (2015) Iron superoxide dismutases in eukaryotic pathogens: new insights from Apicomplexa and Trypanosoma structures. Acta Crystallographica. Section F, Structural Biology Communications. 71: 615-21
Gelinas AD, Davies DR, Edwards TE, et al. (2014) Crystal structure of interleukin-6 in complex with a modified nucleic acid ligand. The Journal of Biological Chemistry. 289: 8720-34
Davies DR, Gelinas AD, Zhang C, et al. (2012) Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets. Proceedings of the National Academy of Sciences of the United States of America. 109: 19971-6
Begley DW, Davies DR, Hartley RC, et al. (2011) Probing conformational states of glutaryl-CoA dehydrogenase by fragment screening. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 1060-9
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