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Janet L. Paulsen, Ph.D.

Affiliations: 
2012 Pharmaceutical Sciences University of Connecticut, Storrs, CT, United States 
Area:
X-Ray crystallography, Structural biology, Molecular modeling, Structure-based drug design
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"Janet Paulsen"
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Amy Christine Anderson grad student 2012 University of Connecticut
 (A Structure-Based Drug Design Approach to Develop Dual Action Antimycotics against Candida albicans and Candida glabrata Dihydrofolate Reductase.)

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Publications

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Leidner F, Kurt Yilmaz N, Paulsen J, et al. (2018) Hydration Structure and Dynamics of Inhibitor-Bound HIV-1 Protease. Journal of Chemical Theory and Computation
Khan SN, Persons JD, Paulsen JL, et al. (2018) Probing Structural Changes among Analogous Inhibitor-Bound Forms of HIV-1 Protease and a Drug-Resistant Mutant in Solution by Nuclear Magnetic Resonance. Biochemistry
Paulsen JL, Leidner F, Ragland DA, et al. (2017) Interdependence of Inhibitor Recognition in HIV-1 Protease. Journal of Chemical Theory and Computation
Hilbert BJ, Morris BL, Ellis KC, et al. (2015) Structure-guided design of a high affinity inhibitor to human CtBP. Acs Chemical Biology. 10: 1118-27
Cai Y, Myint W, Paulsen JL, et al. (2014) Drug Resistance Mutations Alter Dynamics of Inhibitor-Bound HIV-1 Protease. Journal of Chemical Theory and Computation. 10: 3438-3448
G-Dayanandan N, Paulsen JL, Viswanathan K, et al. (2014) Propargyl-linked antifolates are dual inhibitors of Candida albicans and Candida glabrata. Journal of Medicinal Chemistry. 57: 2643-56
Paulsen JL, Viswanathan K, Wright DL, et al. (2013) Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species. Bioorganic & Medicinal Chemistry Letters. 23: 1279-84
Paulsen JL, Bendel SD, Anderson AC. (2011) Crystal structures of Candida albicans dihydrofolate reductase bound to propargyl-linked antifolates reveal the flexibility of active site loop residues critical for ligand potency and selectivity. Chemical Biology & Drug Design. 78: 505-12
Algul O, Paulsen JL, Anderson AC. (2011) 2,4-Diamino-5-(2'-arylpropargyl)pyrimidine derivatives as new nonclassical antifolates for human dihydrofolate reductase inhibition. Journal of Molecular Graphics & Modelling. 29: 608-13
Paulsen JL, Anderson AC. (2009) Scoring ensembles of docked protein:ligand interactions for virtual lead optimization. Journal of Chemical Information and Modeling. 49: 2813-9
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