Silvia A. Arredondo, Ph.D.

Affiliations: 
2009 Chemical Engineering University of Texas at Austin, Austin, Texas, U.S.A. 
Area:
discovery and development of protein therapeutics and applied immunology by capitalizing on state of the art protein engineering, directed evolution and systems biology technologies
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"Silvia Arredondo"
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George Georgiou grad student 2009 UT Austin
 (Engineering and characterization of disulfide bond isomerases in Escherichia coli.)
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Publications

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Tonkin ML, Arredondo SA, Loveless BC, et al. (2013) Structural and biochemical characterization of Plasmodium falciparum 12 (Pf12) reveals a unique interdomain organization and the potential for an antiparallel arrangement with Pf41. The Journal of Biological Chemistry. 288: 12805-17
Arredondo SA, Cai M, Takayama Y, et al. (2012) Structure of the Plasmodium 6-cysteine s48/45 domain. Proceedings of the National Academy of Sciences of the United States of America. 109: 6692-7
Arredondo SA, Georgiou G. (2011) The problem of expression of multidisulfide bonded recombinant proteins in E. coli Protein Reviews. 14: 183-215
Arredondo SA, Chen TF, Riggs AF, et al. (2009) Role of dimerization in the catalytic properties of the Escherichia coli disulfide isomerase DsbC. The Journal of Biological Chemistry. 284: 23972-9
Arredondo S, Segatori L, Gilbert HF, et al. (2008) De novo design and evolution of artificial disulfide isomerase enzymes analogous to the bacterial DsbC. The Journal of Biological Chemistry. 283: 31469-76
Segatori L, Murphy L, Arredondo S, et al. (2006) Conserved role of the linker alpha-helix of the bacterial disulfide isomerase DsbC in the avoidance of misoxidation by DsbB. The Journal of Biological Chemistry. 281: 4911-9
Segatori L, Arredondo S, Georgiau G. (2005) De novo engineering of a bacterial disulfide isomerase Aiche Annual Meeting, Conference Proceedings. 8058
Segatori L, Arredondo S, Georgiou G. (2004) Structure-function and de novo design of protein disulfide isomerases Aiche Annual Meeting, Conference Proceedings. 8749
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