Ivan Birukou, Ph.D.

Affiliations: 
2011 Rice University, Houston, TX 
Area:
myoglobin, hemoglobin
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"Ivan Birukou"
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John S. Olson grad student 2011 Rice University
 (Determination of Pathways for Oxygen Binding to Human Hemoglobin A.)
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Publications

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Bissé E, Schaeffer-Reiss C, Van Dorsselaer A, et al. (2016) Hemoglobin Kirklareli (α H58L), a New Variant Associated with Fe Deficiency and Increased CO Binding. The Journal of Biological Chemistry
Esquerra RM, Bibi BM, Tipgunlakant P, et al. (2016) The Role of Heme Pocket Water in Allosteric Regulation of Ligand Reactivity in Human Hemoglobin. Biochemistry
Schindler BD, Seo SM, Birukou I, et al. (2015) Mutations within the mepA operator affect binding of the MepR regulatory protein and its induction by MepA substrates in Staphylococcus aureus. Journal of Bacteriology. 197: 1104-14
Birukou I, Seo SM, Schindler BD, et al. (2014) Structural mechanism of transcription regulation of the Staphylococcus aureus multidrug efflux operon mepRA by the MarR family repressor MepR. Nucleic Acids Research. 42: 2774-88
Birukou I, Tonthat NK, Seo SM, et al. (2013) The molecular mechanisms of allosteric mutations impairing MepR repressor function in multidrug-resistant strains of Staphylococcus aureus. Mbio. 4: e00528-13
Schindler BD, Seo SM, Jacinto PL, et al. (2013) Functional consequences of substitution mutations in MepR, a repressor of the Staphylococcus aureus MepA multidrug efflux pump gene. Journal of Bacteriology. 195: 3651-62
Varnado CL, Mollan TL, Birukou I, et al. (2013) Development of recombinant hemoglobin-based oxygen carriers. Antioxidants & Redox Signaling. 18: 2314-28
Birukou I, Kaatz GW, Brennan RG. (2013) Crystal Structure of a MepR-DNA Complex Reveals the Mechanism of Transcription Repression of S. Aureus Multidrug Efflux Pump mepA Biophysical Journal. 104: 256a
Birukou I, Maillett DH, Birukova A, et al. (2011) Modulating distal cavities in the α and β subunits of human HbA reveals the primary ligand migration pathway. Biochemistry. 50: 7361-74
Birukou I, Soman J, Olson JS. (2011) Blocking the gate to ligand entry in human hemoglobin. The Journal of Biological Chemistry. 286: 10515-29
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