Tsui-Fen Chou, Ph.D.

Affiliations: 
2006 University of Minnesota, Twin Cities, Minneapolis, MN 
Area:
development of approaches that will deliver anticancers drug, proteins and nucleic acids to cancer tissues and not normal tissues
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"Tsui-Fen Chou"
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SNBCP

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Carston R. Wagner grad student 2006 UMN
 (Histidine triad nucleotide binding proteins (Hints): Nucleoside phosphoramidases and potential regulators of aminoacyl-tRNA synthetases.)
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Publications

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Wang F, Li S, Gan T, et al. (2020) Allosteric p97 inhibitors can overcome resistance to ATP-competitive p97 inhibitors for potential anti-cancer therapy. Chemmedchem
LaPorte MG, Burnett JC, Colombo R, et al. (2018) Optimization of Phenyl Indole Inhibitors of the AAA+ ATPase p97. Acs Medicinal Chemistry Letters. 9: 1075-1081
Li J, Zhang Y, Da Silva Sil Dos Santos B, et al. (2018) Epidithiodiketopiperazines Inhibit Protein Degradation by Targeting Proteasome Deubiquitinase Rpn11. Cell Chemical Biology
Srivastava AK, Govindharajulu JP, Hollingshead MG, et al. (2018) Pharmacodynamics of first-in-class p97 inhibitors that disrupt protein homeostasis in cancer. Journal of Clinical Oncology. 36: e14539-e14539
Bastola P, Freudenthal B, Schaich M, et al. (2018) Abstract A40: Specific mutations in the D1-D2 linker region of VCP/p97 enhance ATPase activity and confer resistance to VCP inhibitors Clinical Cancer Research. 24
Sauni CT, Wang F, Kan S, et al. (2018) Pilot enzyme replacement therapy with recombinant human glucosamine (N-acetyl)-6-sulfatase in mucopolysaccharidosis type IIID mouse model Molecular Genetics and Metabolism. 123
Bastola P, Wang F, Schaich MA, et al. (2017) Specific mutations in the D1-D2 linker region of VCP/p97 enhance ATPase activity and confer resistance to VCP inhibitors. Cell Death Discovery. 3: 17065
Nakasone MA, Lewis TA, Walker O, et al. (2017) Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway. Structure (London, England : 1993)
Shah R, Chou TF, Maize KM, et al. (2017) Inhibition by divalent metal ions of human histidine triad nucleotide binding protein1 (hHint1), a regulator of opioid analgesia and neuropathic pain. Biochemical and Biophysical Research Communications
Lee Y, Chou TF, Pittman SK, et al. (2017) Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination. Cell Reports. 19: 188-202
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