Wai L. Lau, Ph.D.

Affiliations: 
2003 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Organic Chemistry, Chemical Biology, De Novo Protein Design
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"Wai Lau"
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William F. DeGrado grad student 2003 Penn
 (Folding dynamics and membrane fusion mediated by model coiled -coil peptides.)
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Publications

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Lau WL, Degrado WF, Roder H. (2010) The effects of pK(a) tuning on the thermodynamics and kinetics of folding: design of a solvent-shielded carboxylate pair at the a-position of a coiled-coil. Biophysical Journal. 99: 2299-308
Wang T, Lau WL, DeGrado WF, et al. (2005) T-jump infrared study of the folding mechanism of coiled-coil GCN4-p1. Biophysical Journal. 89: 4180-7
Lau WL, Ege DS, Lear JD, et al. (2004) Oligomerization of fusogenic peptides promotes membrane fusion by enhancing membrane destabilization. Biophysical Journal. 86: 272-84
Talaga DS, Lau WL, Roder H, et al. (2000) Dynamics and folding of single two-stranded coiled-coil peptides studied by fluorescent energy transfer confocal microscopy. Proceedings of the National Academy of Sciences of the United States of America. 97: 13021-6
Jia Y, Talaga DS, Lau WL, et al. (1999) Folding dynamics of single GCN-4 peptides by fluorescence resonant energy transfer confocal microscopy Chemical Physics. 247: 69-83
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