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David M. Bartley, Ph.D.

Affiliations: 
2004 University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
design potent and specific "mechanism-based inhibitors" of selected target enzymes for use as drugs in the treatment of cancer and parasitic diseases
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"David Bartley"
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Parents

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Laura J Smith grad student University of Michigan
James K. Coward grad student 2004 University of Michigan
 (Synthesis of phosphorus containing pseudopeptide inhibitors of folylpolyglutamate synthetase.)

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McGuire JJ, Bartley DM, Tomsho JW, et al. (2010) Corrigendum to "Inhibition of human folylpolyglutamate synthetase by diastereomeric phosphinic acid mimics of the tetrahedral intermediate" [Archives of Biochemistry and Biophysics 488 (2009) 140-145] (DOI:10.1016/j.abb.2009.06.017) Archives of Biochemistry and Biophysics. 493: 250
McGuire JJ, Bartley DM, Tomsho JW, et al. (2009) Inhibition of human folylpolyglutamate synthetase by diastereomeric phosphinic acid mimics of the tetrahedral intermediate. Archives of Biochemistry and Biophysics. 488: 140-5
Bartley DM, Coward JK. (2006) Regioselective synthesis of alpha-methyl 2-methyleneglutarate via a novel lactonization-elimination rearrangement. The Journal of Organic Chemistry. 71: 372-4
Bartley DM, Coward JK. (2005) A stereoselective synthesis of phosphinic acid phosphapeptides corresponding to glutamyl-gamma-glutamate and incorporation into potent inhibitors of folylpoly-gamma-glutamyl synthetase. The Journal of Organic Chemistry. 70: 6757-74
McGuire JJ, Haile WH, Valiaeva N, et al. (2003) Potent inhibition of human folylpolyglutamate synthetase by a phosphinic acid mimic of the tetrahedral reaction intermediate. Biochemical Pharmacology. 65: 315-8
Valiaeva N, Bartley D, Konno T, et al. (2001) Phosphinic acid pseudopeptides analogous to glutamyl-gamma-glutamate: synthesis and coupling to pteroyl azides leads to potent inhibitors of folylpoly-gamma-glutamate synthetase. The Journal of Organic Chemistry. 66: 5146-54
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