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Changho Han, Ph.D.

Affiliations: 
2013 Medicinal Chemistry and Molecular Pharmacology Purdue University, West Lafayette, IN, United States 
Area:
natural product synthesis
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"Changho Han"
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David A. Colby grad student 2013 Purdue
 (Discovery of the trifluoroacetate release process and its strategic application toward the synthesis of biologically active molecules.)

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Publications

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Khatri HR, Han C, Alkhodier RA, et al. (2022) Generation of formaldehyde and formaldehyde-d for hydroxymethylations and hydroxydeuteromethylations of difluoroenolates and difluorobenzyl carbanions. Chemical Communications (Cambridge, England). 58: 5490-5493
Khatri HR, Han C, Luong E, et al. (2019) Controlling the Cleavage of Carbon-Carbon Bonds to Generate α,α-Difluorobenzyl Carbanions for the Construction of Difluoromethylbenzenes. The Journal of Organic Chemistry
Sowaileh MF, Han C, Hazlitt RA, et al. (2017) Conversion of Methyl Ketones and Methyl Sulfones into α-Deutero-α,α-Difluoromethyl Ketones and α-Deutero-α,α-Difluoromethyl Sulfones in Three Synthetic Steps. Tetrahedron Letters. 58: 396-400
Han C, Salyer AE, Kim EH, et al. (2013) Evaluation of difluoromethyl ketones as agonists of the γ-aminobutyric acid type B (GABAB) receptor. Journal of Medicinal Chemistry. 56: 2456-65
Han C, Kim EH, Colby DA. (2012) Cleaving carbon-carbon bonds by the release of trifluoroacetate to remodel molecules and assemble fluorinated structures Synlett. 23: 1559-1563
Han C, Kim EH, Colby DA. (2011) Cleavage of carbon-carbon bonds through the mild release of trifluoroacetate: generation of α,α-difluoroenolates for aldol reactions. Journal of the American Chemical Society. 133: 5802-5
Gunn EJ, Williams JT, Huynh DT, et al. (2011) The natural products parthenolide and andrographolide exhibit anti-cancer stem cell activity in multiple myeloma. Leukemia & Lymphoma. 52: 1085-97
Huynh DT, Iannotti MJ, Gunn EJ, et al. (2010) Abstract 4292: Parthenolide and structurally related natural products as anti-cancer stem cell agents: A new era in treatment of multiple myeloma Cancer Research. 70: 4292-4292
Han C, Barrios FJ, Riofski MV, et al. (2010) ChemInform Abstract: Semisynthetic Derivatives of Sesquiterpene Lactones by Palladium-Catalyzed Arylation of the α-Methylene-γ-lactone Substructure. Cheminform. 41
Han C, Barrios FJ, Riofski MV, et al. (2009) Semisynthetic derivatives of sesquiterpene lactones by palladium-catalyzed arylation of the alpha-methylene-gamma-lactone substructure. The Journal of Organic Chemistry. 74: 7176-9
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