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Jillian Orans, Ph.D.

Affiliations: 
2007 Chemistry University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Structural Studies of Dynamic Cellular Processes
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"Jillian Orans"
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Matthew R. Redinbo grad student 2007 UNC Chapel Hill
 (Structural studies of Pseudomonas aeruginosa pilY1, a protein central to infections in Cystic Fibrosis.)

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Publications

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Orans J, Kovach AR, Hoff KE, et al. (2020) Crystal structure of an Escherichia coli Hfq Core (residues 2-69)-DNA complex reveals multifunctional nucleic acid binding sites. Nucleic Acids Research
Kovach AR, Hoff KE, Canty JT, et al. (2014) Recognition of U-rich RNA by Hfq from the Gram-positive pathogen Listeria monocytogenes. Rna (New York, N.Y.). 20: 1548-59
Robinson KE, Orans J, Kovach AR, et al. (2014) Mapping Hfq-RNA interaction surfaces using tryptophan fluorescence quenching. Nucleic Acids Research. 42: 2736-49
Horstmann N, Orans J, Valentin-Hansen P, et al. (2012) Structural mechanism of Staphylococcus aureus Hfq binding to an RNA A-tract. Nucleic Acids Research. 40: 11023-35
Tseng Q, Orans J, Hast MA, et al. (2011) Purification, crystallization and preliminary X-ray diffraction analysis of the human mismatch repair protein MutSβ. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 947-52
Orans J, McSweeney EA, Iyer RR, et al. (2011) Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family. Cell. 145: 212-23
Orans J, McSweeney E, Modrich P, et al. (2011) Crystal Structures of Human Exonuclease I with DNA Provides Insight into Substrate Selectivity and Mechanism Biophysical Journal. 100: 241a
Wallace BD, Wang H, Lane KT, et al. (2010) Alleviating cancer drug toxicity by inhibiting a bacterial enzyme. Science (New York, N.Y.). 330: 831-5
Orans J, Johnson MD, Coggan KA, et al. (2010) Crystal structure analysis reveals Pseudomonas PilY1 as an essential calcium-dependent regulator of bacterial surface motility. Proceedings of the National Academy of Sciences of the United States of America. 107: 1065-70
Orans J, Johnson MDL, Coggan KA, et al. (2010) Crystal structure analysis reveals Pseudomonas PilY1 as an essential calcium-dependent regulator of bacterial surface motility (Proceedings of the National Academy of Sciences of the United States of America (2010) 107, 3 (1065-1070) DOI:10.1073/pnas.0911616107) Proceedings of the National Academy of Sciences of the United States of America. 107: 5260
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