Jooyoung Cha, Ph.D.

Affiliations: 
2007 University of Notre Dame, Notre Dame, IN, United States 
Area:
bioorganic chemistry, organic synthesis, protein chemistry, enzymology and computational sciences
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"Jooyoung Cha"
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Shahriar Mobashery grad student 2007 Notre Dame
 (Penicillin -binding proteins in pathogens: Characterizations of catalytic properties in antibiotic resistance.)
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Publications

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Rhee SJ, Hong HS, Kim CH, et al. (2015) Using Acoustic Structure Quantification During B-Mode Sonography for Evaluation of Hashimoto Thyroiditis. Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine
Frederick TE, Wilson BD, Cha J, et al. (2014) Revealing cell-surface intramolecular interactions in the BlaR1 protein of methicillin-resistant Staphylococcus aureus by NMR spectroscopy. Biochemistry. 53: 10-2
Totir MA, Cha J, Ishiwata A, et al. (2008) Why clinically used tazobactam and sulbactam are poor inhibitors of OXA-10 beta-lactamase: Raman crystallographic evidence. Biochemistry. 47: 4094-101
Cha J, Vakulenko SB, Mobashery S. (2007) Characterization of the beta-lactam antibiotic sensor domain of the MecR1 signal sensor/transducer protein from methicillin-resistant Staphylococcus aureus. Biochemistry. 46: 7822-31
Cha J, Mobashery S. (2007) Lysine N(zeta)-decarboxylation in the BlaR1 protein from Staphylococcus aureus at the root of its function as an antibiotic sensor. Journal of the American Chemical Society. 129: 3834-5
Thumanu K, Cha J, Fisher JF, et al. (2006) Discrete steps in sensing of beta-lactam antibiotics by the BlaR1 protein of the methicillin-resistant Staphylococcus aureus bacterium. Proceedings of the National Academy of Sciences of the United States of America. 103: 10630-5
Kim C, Cha JY, Yan H, et al. (2006) Hydrolysis of ATP by aminoglycoside 3'-phosphotransferases: an unexpected cost to bacteria for harboring an antibiotic resistance enzyme. The Journal of Biological Chemistry. 281: 6964-9
Birck C, Cha JY, Cross J, et al. (2004) X-ray crystal structure of the acylated beta-lactam sensor domain of BlaR1 from Staphylococcus aureus and the mechanism of receptor activation for signal transduction. Journal of the American Chemical Society. 126: 13945-7
Cha JY, Ishiwata A, Mobashery S. (2004) A novel beta-lactamase activity from a penicillin-binding protein of Treponema pallidum and why syphilis is still treatable with penicillin. The Journal of Biological Chemistry. 279: 14917-21
Golemi-Kotra D, Cha JY, Meroueh SO, et al. (2003) Resistance to beta-lactam antibiotics and its mediation by the sensor domain of the transmembrane BlaR signaling pathway in Staphylococcus aureus. The Journal of Biological Chemistry. 278: 18419-25
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