Yi Wu, Ph.D.

Affiliations: 
2004 Northwestern University, Evanston, IL 
Area:
molecular mechanisms of metastasis
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"Yi Wu"
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M. Sharon Stack grad student 2004 Northwestern
 (Dynamic regulation of membrane type 1-matrix metalloproteinase.)
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Publications

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Moss NM, Wu YI, Liu Y, et al. (2009) Modulation of the membrane type 1 matrix metalloproteinase cytoplasmic tail enhances tumor cell invasion and proliferation in three-dimensional collagen matrices. The Journal of Biological Chemistry. 284: 19791-9
Wu YI, Munshi HG, Snipas SJ, et al. (2007) Activation-coupled membrane-type 1 matrix metalloproteinase membrane trafficking. The Biochemical Journal. 407: 171-7
Wolf K, Wu YI, Liu Y, et al. (2007) Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion. Nature Cell Biology. 9: 893-904
Munshi HG, Wu YI, Mukhopadhyay S, et al. (2004) Differential regulation of membrane type 1-matrix metalloproteinase activity by ERK 1/2- and p38 MAPK-modulated tissue inhibitor of metalloproteinases 2 expression controls transforming growth factor-beta1-induced pericellular collagenolysis. The Journal of Biological Chemistry. 279: 39042-50
Tam EM, Morrison CJ, Wu YI, et al. (2004) Membrane protease proteomics: Isotope-coded affinity tag MS identification of undescribed MT1-matrix metalloproteinase substrates. Proceedings of the National Academy of Sciences of the United States of America. 101: 6917-22
Wu YI, Munshi HG, Sen R, et al. (2004) Glycosylation broadens the substrate profile of membrane type 1 matrix metalloproteinase. The Journal of Biological Chemistry. 279: 8278-89
Munshi HG, Wu YI, Ariztia EV, et al. (2002) Calcium regulation of matrix metalloproteinase-mediated migration in oral squamous cell carcinoma cells. The Journal of Biological Chemistry. 277: 41480-8
Tam EM, Wu YI, Butler GS, et al. (2002) Collagen binding properties of the membrane type-1 matrix metalloproteinase (MT1-MMP) hemopexin C domain. The ectodomain of the 44-kDa autocatalytic product of MT1-MMP inhibits cell invasion by disrupting native type I collagen cleavage. The Journal of Biological Chemistry. 277: 39005-14
Munshi HG, Ghosh S, Mukhopadhyay S, et al. (2002) Proteinase suppression by E-cadherin-mediated cell-cell attachment in premalignant oral keratinocytes. The Journal of Biological Chemistry. 277: 38159-67
Ghosh S, Wu Y, Stack MS. (2002) Ovarian cancer-associated proteinases. Cancer Treatment and Research. 107: 331-51
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