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Jessica A. Brown, Ph.D.

Affiliations: 
2010 Biochemistry Program, Ohio State Ohio State University, Columbus, Columbus, OH 
Area:
enzymes involved in DNA/RNA replication, Hepatitis C replication, drug design
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"Jessica Brown"
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Parents

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Zucai Suo grad student 2010 Ohio State
 (Kinetic Mechanisms of DNA Polymerases.)

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Publications

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Kunkler CN, Schiefelbein GE, O'Leary NJ, et al. (2022) A single natural RNA modification can destabilize a U•A-T-rich RNA•DNA-DNA triple helix. Rna (New York, N.Y.)
Kunkler CN, Hulewicz JP, Hickman SC, et al. (2019) Stability of an RNA•DNA-DNA triple helix depends on base triplet composition and length of the RNA third strand. Nucleic Acids Research
Sundar R, Brown J, Ingles Russo A, et al. (2017) Targeting ATR in cancer medicine. Current Problems in Cancer
Leung GP, Brown JA, Glover JN, et al. (2015) Rtt107 BRCT domains act as a targeting module in the DNA damage response. Dna Repair. 37: 22-32
Brown JA, Pack LR, Fowler JD, et al. (2012) Presteady state kinetic investigation of the incorporation of anti-hepatitis B nucleotide analogues catalyzed by noncanonical human DNA polymerases. Chemical Research in Toxicology. 25: 225-33
Brown JA, Suo Z. (2011) Unlocking the sugar "steric gate" of DNA polymerases. Biochemistry. 50: 1135-42
Brown JA, Pack LR, Fowler JD, et al. (2011) Pre-steady-state kinetic analysis of the incorporation of anti-HIV nucleotide analogs catalyzed by human X- and Y-family DNA polymerases. Antimicrobial Agents and Chemotherapy. 55: 276-83
Brown JA, Pack LR, Sanman LE, et al. (2011) Efficiency and fidelity of human DNA polymerases λ and β during gap-filling DNA synthesis. Dna Repair. 10: 24-33
Brown JA, Pack LR, Sherrer SM, et al. (2010) Identification of critical residues for the tight binding of both correct and incorrect nucleotides to human DNA polymerase λ. Journal of Molecular Biology. 403: 505-15
Brown JA, Zhang L, Sherrer SM, et al. (2010) Pre-Steady-State Kinetic Analysis of Truncated and Full-Length Saccharomyces cerevisiae DNA Polymerase Eta. Journal of Nucleic Acids. 2010
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