Denis M. Daigle, Ph.D.
Affiliations: | 2003 | McMaster University, Hamilton, ON, Canada |
Area:
Antibiotic resistance; chemically synthesizing antibioticsGoogle:
"Denis Daigle"Mean distance: 8.51 | S | N | B | C | P |
Parents
Sign in to add mentor| Gerard D. Wright | grad student | 2003 | McMaster University | |
| (Characterization of AAC(6')-APH(2''), a bifunctional aminoglycoside modifying enzyme.) | ||||
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Publications
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| Karlowsky JA, Hackel MA, Wise MG, et al. (2022) Activity of Cefepime-Taniborbactam and Comparators against Clinical Isolates of Gram-Negative Bacilli from 2018 to 2020: Results from the Global Evaluation of Antimicrobial Resistance via Surveillance (GEARS) Program. Antimicrobial Agents and Chemotherapy. e0128122 |
| Roach EJ, Uehara T, Daigle DM, et al. (2021) The Next-Generation β-Lactamase Inhibitor Taniborbactam Restores the Morphological Effects of Cefepime in KPC-Producing Escherichia coli. Microbiology Spectrum. e0091821 |
| Trout RE, Zulli A, Mesaros E, et al. (2021) Discovery of VNRX-7145 (VNRX-5236 Etzadroxil): An Orally Bioavailable β-Lactamase Inhibitor for Enterobacterales Expressing Ambler Class A, C, and D Enzymes. Journal of Medicinal Chemistry |
| Chatwin CL, Hamrick JC, Trout REL, et al. (2021) Microbiological characterization of VNRX-5236: a broad spectrum β-lactamase inhibitor for rescue of the orally bioavailable cephalosporin ceftibuten as a carbapenem-sparing agent against strains of Enterobacterales expressing extended spectrum β-lactamases and serine carbapenemases. Antimicrobial Agents and Chemotherapy |
| Hamrick JC, Docquier JD, Uehara T, et al. (2019) VNRX-5133 (Taniborbactam), a broad-spectrum inhibitor of serine- and metallo-β-lactamases, restores activity of cefepime in and . Antimicrobial Agents and Chemotherapy |
| Liu B, Trout REL, Chu GH, et al. (2019) Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-Lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections. Journal of Medicinal Chemistry |
| Daigle D, Vernacchio S, Xerri L, et al. (2018) 1395. Defining the Magnitude of AUC:MIC Driver for Efficacy of the β-Lactamase Inhibitor VNRX-5133 When Combined with Cefepime Against KPC- and VIM/NDM-Producing Enterobacteriaceae and P. aeruginosa Open Forum Infectious Diseases. 5: S429-S429 |
| Daigle D, Hamrick J, Chatwin C, et al. (2018) 1370. Cefepime/VNRX-5133 Broad-Spectrum Activity Is Maintained Against Emerging KPC- and PDC-Variants in Multidrug-Resistant K. pneumoniae and P. aeruginosa Open Forum Infectious Diseases. 5: S419-S420 |
| Fetar H, Gilmour C, Klinoski R, et al. (2011) mexEF-oprN multidrug efflux operon of Pseudomonas aeruginosa: regulation by the MexT activator in response to nitrosative stress and chloramphenicol. Antimicrobial Agents and Chemotherapy. 55: 508-14 |
| Caughlan RE, Sriram S, Daigle DM, et al. (2009) Fmt bypass in Pseudomonas aeruginosa causes induction of MexXY efflux pump expression. Antimicrobial Agents and Chemotherapy. 53: 5015-21 |