Shugui Chen, Ph.D.
Affiliations: | 2008 | Chemistry | Northeastern University, Boston, MA, United States |
Area:
Bioanalytical chemistry, mass spectrometry, hydrogen/deuterium exchangeGoogle:
"Shugui Chen"Mean distance: 10.98 | S | N | B | C | P |
Parents
Sign in to add mentor| John R. Engen | grad student | 2008 | Northeastern University | |
| (Hydrogen /deuterium exchange mass spectrometry reveals the details of intramolecular interactions that affect Abelson tyrosine kinase activity.) | ||||
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Publications
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| Zhang T, Chen S, Harmon AC. (2015) Protein-protein interactions in plant mitogen-activated protein kinase cascades. Journal of Experimental Botany |
| Engen JR, Wales TE, Chen S, et al. (2013) Partial cooperative unfolding in proteins as observed by hydrogen exchange mass spectrometry. International Reviews in Physical Chemistry. 32: 96-127 |
| Panjarian S, Iacob RE, Chen S, et al. (2013) Structure and dynamic regulation of Abl kinases. The Journal of Biological Chemistry. 288: 5443-50 |
| Panjarian S, Iacob RE, Chen S, et al. (2013) Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitors. The Journal of Biological Chemistry. 288: 6116-29 |
| Panjarian SB, Chen S, Iacob R, et al. (2012) Abstract 5599: Allosteric regulation of Abl and Bcr-Abl kinases by enhanced SH3:linker interaction Cancer Research. 72: 5599-5599 |
| Panjarian SB, Chen S, Iacob R, et al. (2011) Abstract B75: Allosteric regulation of Abl and Bcr-Abl kinases by enhanced SH3:linker interaction. Molecular Cancer Therapeutics. 10 |
| Panjarian S, Chen S, Engen J, et al. (2010) Enhanced SH3:Linker Interaction Suppresses Activating Mutations of the c-Abl Protein-Tyrosine Kinase. Blood. 116: 1208-1208 |
| Chen S, Engen JR. (2009) Isotope exchange and covalent modification strategies for studying protein structure and function Current Analytical Chemistry. 5: 205-212 |
| Chen S, O'Reilly LP, Smithgall TE, et al. (2008) Tyrosine phosphorylation in the SH3 domain disrupts negative regulatory interactions within the c-Abl kinase core. Journal of Molecular Biology. 383: 414-23 |
| Chen S, Dumitrescu TP, Smithgall TE, et al. (2008) Abl N-terminal cap stabilization of SH3 domain dynamics. Biochemistry. 47: 5795-803 |