jian zhang
Affiliations: | Shanghai Jiao Tong University School of Medicine |
Area:
Molecular DesignWebsite:
http://mdl.shsmu.edu.cn/Google:
"jian zhang"Bio:
Professor
Molecular Design Laboratory
Institute of Medical Science
Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education
School of Medicine
Shanghai Jiaotong University
Room 1006&1008, 280 Chongqing Road, Building 2, Shanghai 20025, China
Tel: 86-21-63846590-776922
Fax: 86-21-64154900
E-mail: jian.zhang@sjtu.edu.cn & jzhang.dr@gmail.com
Mean distance: 10.41 | S | N | B | C | P |
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Publications
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| Shang JL, Ning SB, Chen YY, et al. (2020) MDL-800, an allosteric activator of SIRT6, suppresses proliferation and enhances EGFR-TKIs therapy in non-small cell lung cancer. Acta Pharmacologica Sinica |
| Zhang X, Shi S, Su Y, et al. (2020) Suramin and NF449 are IP5K inhibitors that disrupt IP6-mediated regulation of cullin RING ligase and sensitize cancer cells to MLN4924/pevonedistat. The Journal of Biological Chemistry |
| Shang J, Zhu Z, Chen Y, et al. (2020) Small-molecule activating SIRT6 elicits therapeutic effects and synergistically promotes anti-tumor activity of vitamin D in colorectal cancer. Theranostics. 10: 5845-5864 |
| Qin J, Shen X, Zhang J, et al. (2020) Allosteric inhibitors of the STAT3 signaling pathway. European Journal of Medicinal Chemistry. 190: 112122 |
| Lu S, Chen Y, Wei J, et al. (2020) Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators Acta Pharmaceutica Sinica B |
| Huang K, Liang Q, Zhou Y, et al. (2019) A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer. Cell Metabolism |
| Wang L, Zhang L, Li L, et al. (2019) Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer. Science Advances. 5: eaax2277 |
| Yao H, Tang H, Zhang Y, et al. (2019) DEPTOR inhibits cell proliferation and confers sensitivity to dopamine agonist in pituitary adenoma. Cancer Letters |
| Xu X, Chen Y, Fu Q, et al. (2019) The chemical diversity and structure-based discovery of allosteric modulators for the PIF-pocket of protein kinase PDK1. Journal of Enzyme Inhibition and Medicinal Chemistry. 34: 361-374 |
| Yang X, Deng M, Zhang X, et al. (2018) Design, Synthesis, and Biological Evaluation of Thieno[3,2-d]pyrimidine Derivatives as Potential Simplified Phosphatidylinositol 3-Kinase alpha (PI3Kα) inhibitors. Chemical Biology & Drug Design |