Christian M. Metallo, Ph.D.

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2008 University of Wisconsin, Madison, Madison, WI 
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Juan  J. de Pablo grad student 2008 UW Madison
 (Directed differentiation of pluripotent human cells to epithelial lineages.)
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Publications

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Muta Y, Linares JF, Martinez-Ordoñez A, et al. (2023) Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis. Nature Communications. 14: 8075
Zhang J, Keibler MA, Dong W, et al. (2023) Stable Isotope-Assisted Untargeted Metabolomics Identifies ALDH1A1-Driven Erythronate Accumulation in Lung Cancer Cells. Biomedicines. 11
Kuna RS, Kumar A, Wessendorf-Rodriguez KA, et al. (2023) Inter-organelle cross-talk supports acetyl-coenzyme A homeostasis and lipogenesis under metabolic stress. Science Advances. 9: eadf0138
Cordes T, Kuna RS, McGregor GH, et al. (2022) 1-Deoxysphingolipid synthesis compromises anchorage-independent growth and plasma membrane endocytosis in cancer cells. Journal of Lipid Research. 63: 100281
Kumar A, Cordes T, Thalacker-Mercer AE, et al. (2021) NaCT/SLC13A5 facilitates citrate import and metabolism under nutrient-limited conditions. Cell Reports. 36: 109701
Ravi A, Palamiuc L, Loughran RM, et al. (2021) PI5P4Ks drive metabolic homeostasis through peroxisome-mitochondria interplay. Developmental Cell
Cordes T, Metallo CM. (2021) Itaconate Alters Succinate and Coenzyme A Metabolism via Inhibition of Mitochondrial Complex II and Methylmalonyl-CoA Mutase. Metabolites. 11
Cordes T, Metallo CM. (2020) Exploring the evolutionary roots and physiological function of itaconate. Current Opinion in Biotechnology. 68: 144-150
Muthusamy T, Cordes T, Handzlik MK, et al. (2020) Serine restriction alters sphingolipid diversity to constrain tumour growth. Nature
Feyen DAM, McKeithan WL, Bruyneel AAN, et al. (2020) Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes. Cell Reports. 32: 107925
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