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Carl S. Rye, Ph.D.

Affiliations: 
2002 University of British Columbia, Vancouver, Vancouver, BC, Canada 
Area:
enzyme mechanisms, protein structure/function relationships, enzyme inhibitor design/synthesis and protein engineering
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"Carl Rye"
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Stephen G. Withers grad student 2002 UBC
 (Mechanistic studies of chondroitin AC lyase from Flavobacterium heparinum.)

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Publications

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Meyers J, Chessum NEA, Ali S, et al. (2018) Privileged Structures and Polypharmacology within and between Protein Families. Acs Medicinal Chemistry Letters. 9: 1199-1204
Cheeseman MD, Chessum NE, Rye CS, et al. (2017) Abstract LB-304: Discovery of chemical probe CCT251236: An orally bioavailable efficacious pirin ligand from an HSF1 phenotypic screen Cancer Research. 77
Cheeseman MD, Chessum NE, Rye CS, et al. (2016) Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen. Journal of Medicinal Chemistry
Rye CS, Chessum NE, Lamont S, et al. (2016) Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9. Medchemcomm. 7: 1580-1586
Rye CS, Baell JB, Street I. (2007) Synthesis, reactivity and applications of 1-fluoroalkyl carboxylates: novel synthetic substrates for esterases and lipases Tetrahedron. 63: 3306-3311
Rye CS, Matte A, Cygler M, et al. (2006) An atypical approach identifies TYR234 as the key base catalyst in chondroitin AC lyase. Chembiochem : a European Journal of Chemical Biology. 7: 631-7
Rye CS, Withers SG. (2004) The synthesis of a novel thio-linked disaccharide of chondroitin as a potential inhibitor of polysaccharide lyases. Carbohydrate Research. 339: 699-703
Rye CS, Withers SG. (2002) Development of an assay and determination of kinetic parameters for chondroitin AC lyase using defined synthetic substrates. Analytical Biochemistry. 308: 77-82
Rye CS, Withers SG. (2002) Elucidation of the mechanism of polysaccharide cleavage by chondroitin AC lyase from Flavobacterium heparinum. Journal of the American Chemical Society. 124: 9756-67
Rye CS, Withers SG. (2002) Synthesis and evaluation of potential inhibitors of chondroitin AC lyase from Flavobacterium heparinum. The Journal of Organic Chemistry. 67: 4505-12
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