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Susan L. Mercer, Ph.D.

Affiliations: 
2008 Pharmaceutical Sciences University of Maryland School of Medicine, Baltimore, MD, United States 
Area:
Opioid synthesis
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"Susan Mercer"
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Andrew Coop grad student 2008 University of Maryland Medical School
 (Synthesis and characterization of meperidine analogs at the P-glycoprotein efflux transporter.)

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Burns SM, Cunningham CW, Mercer SL. (2018) DARK Classics in Chemical Neuroscience: Fentanyl. Acs Chemical Neuroscience
Devereaux AL, Mercer SL, Cunningham CW. (2018) DARK Classics in Chemical Neuroscience: Morphine. Acs Chemical Neuroscience
Metcalf MD, Rosicky AD, Hassan HE, et al. (2014) Opioids and efflux transporters. Part 4: influence of N-substitution on P-glycoprotein substrate activity of noroxymorphone analogues. Bioorganic & Medicinal Chemistry Letters. 24: 3592-5
Mercer SL, Coop A. (2011) Opioid analgesics and P-glycoprotein efflux transporters: a potential systems-level contribution to analgesic tolerance. Current Topics in Medicinal Chemistry. 11: 1157-64
Koek W, Mercer SL, Coop A, et al. (2009) Behavioral effects of gamma-hydroxybutyrate, its precursor gamma-butyrolactone, and GABA(B) receptor agonists: time course and differential antagonism by the GABA(B) receptor antagonist 3-aminopropyl(diethoxymethyl)phosphinic acid (CGP35348). The Journal of Pharmacology and Experimental Therapeutics. 330: 876-83
Hassan HE, Mercer SL, Cunningham CW, et al. (2009) Evaluation of the P-glycoprotein (Abcb1) affinity status of a series of morphine analogs: comparative study with meperidine analogs to identify opioids with minimal P-glycoprotein interactions. International Journal of Pharmaceutics. 375: 48-54
Mercer SL, Cunningham CW, Eddington ND, et al. (2008) Opioids and efflux transporters. Part 3: P-glycoprotein substrate activity of 3-hydroxyl addition to meperidine analogs. Bioorganic & Medicinal Chemistry Letters. 18: 3638-40
Cunningham CW, Mercer SL, Hassan HE, et al. (2008) Opioids and efflux transporters. Part 2: P-glycoprotein substrate activity of 3- and 6-substituted morphine analogs. Journal of Medicinal Chemistry. 51: 2316-20
Mercer SL, Shaikh J, Traynor JR, et al. (2008) Nitrile analogs of meperidine as high affinity and selective sigma-1 receptor ligands. European Journal of Medicinal Chemistry. 43: 1304-8
Koek W, Mercer SL, Coop A. (2007) Cataleptic effects of gamma-hydroxybutyrate (GHB), its precursor gamma-butyrolactone (GBL), and GABAB receptor agonists in mice: differential antagonism by the GABAB receptor antagonist CGP35348. Psychopharmacology. 192: 407-14
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