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Thomas H. Charpentier, Ph.D.

Affiliations: 
2009 Biochemistry University of Maryland School of Medicine, Baltimore, MD, United States 
Area:
structure and function of S100B, a growth factor in the brain and skin
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"Thomas Charpentier"
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David J. Weber grad student 2009 University of Maryland Medical School
 (Structure, function, and inhibition of S100B.)

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Charpentier TH, Waldo GL, Lowery-Gionta EG, et al. (2016) Potent and Selective Peptide-based Inhibition of the G protein Gαq. The Journal of Biological Chemistry
Cavalier MC, Ansari MI, Pierce AD, et al. (2016) Small Molecule Inhibitors of Ca(2+)-S100B Reveal Two Protein Conformations. Journal of Medicinal Chemistry
Schrage R, Schmitz AL, Gaffal E, et al. (2015) The experimental power of FR900359 to study Gq-regulated biological processes. Nature Communications. 6: 10156
Schmitz AL, Schrage R, Gaffal E, et al. (2014) A cell-permeable inhibitor to trap Gαq proteins in the empty pocket conformation. Chemistry & Biology. 21: 890-902
Hajicek N, Charpentier TH, Rush JR, et al. (2013) Autoinhibition and phosphorylation-induced activation of phospholipase C-γ isozymes. Biochemistry. 52: 4810-9
Wilder PT, Charpentier TH, Liriano MA, et al. (2010) In vitro screening and structural characterization of inhibitors of the S100B-p53 interaction. International Journal of High Throughput Screening. 2010: 109-126
Charpentier TH, Thompson LE, Liriano MA, et al. (2010) The effects of CapZ peptide (TRTK-12) binding to S100B-Ca2+ as examined by NMR and X-ray crystallography. Journal of Molecular Biology. 396: 1227-43
Charpentier TH, Wilder PT, Liriano MA, et al. (2009) Small molecules bound to unique sites in the target protein binding cleft of calcium-bound S100B as characterized by nuclear magnetic resonance and X-ray crystallography. Biochemistry. 48: 6202-12
Charpentier TH, Wilder PT, Liriano MA, et al. (2008) Divalent metal ion complexes of S100B in the absence and presence of pentamidine. Journal of Molecular Biology. 382: 56-73
Malashkevich VN, Varney KM, Garrett SC, et al. (2008) Structure of Ca2+-bound S100A4 and its interaction with peptides derived from nonmuscle myosin-IIA. Biochemistry. 47: 5111-26
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