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Hyuk-Soo Seo, Ph.D.

Affiliations: 
2004 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Biological
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"Hyuk-Soo Seo"
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Barry S. Cooperman grad student 2004 Penn
 (Studies on the dynamic nature of GTPase activation center of Escherichia coli ribosomes using chemical probes and fast kinetics.)

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Publications

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Fan M, Lu W, Che J, et al. (2022) Covalent disruptor of YAP-TEAD association suppresses defective hippo signaling. Elife. 11
Pinch BJ, Doctor ZM, Nabet B, et al. (2020) Identification of a potent and selective covalent Pin1 inhibitor. Nature Chemical Biology
Harvey EP, Hauseman ZJ, Cohen DT, et al. (2020) Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering. Cell Chemical Biology
Ben-Nun Y, Seo HS, Harvey EP, et al. (2020) Identification of a Structural Determinant for Selective Targeting of HDMX. Structure (London, England : 1993)
Manz TD, Sivakumaren SC, Ferguson FM, et al. (2020) Discovery and Structure-Activity Relationship Study of (Z)-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors. Journal of Medicinal Chemistry
Manz TD, Sivakumaren SC, Yasgar A, et al. (2020) Structure-Activity Relationship Study of Covalent Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors. Acs Medicinal Chemistry Letters. 11: 346-352
Sivakumaren SC, Shim H, Zhang T, et al. (2020) Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors. Cell Chemical Biology
Blus BJ, Koh J, Krolak A, et al. (2019) Allosteric modulation of nucleoporin assemblies by intrinsically disordered regions. Science Advances. 5: eaax1836
Valencia AM, Collings CK, Dao HT, et al. (2019) Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling. Cell
de Araujo ED, Orlova A, Neubauer HA, et al. (2019) Structural Implications of STAT3 and STAT5 SH2 Domain Mutations. Cancers. 11
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