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William M. Lindstrom, Ph.D.

Affiliations: 
2000 University of California, Santa Barbara, Santa Barbara, CA, United States 
Area:
Materials Chemistry, Biochemistry & Biophysics, Biomedical Sciences, Biology-Inspired Chemistry & Physics, Deivces, Assembly & Nanochemistry, Structural Chemistry, Spectroscopy & Advanced Analysis
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"William Lindstrom"
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Norbert O. Reich grad student 2000 UC Santa Barbara
 (The enzymology of bacterial DNA methyltransferases.)

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Malygin EG, Lindstrom WM, Zinoviev VV, et al. (2003) Bacteriophage T4Dam (DNA-(adenine-N6)-methyltransferase): evidence for two distinct stages of methylation under single turnover conditions. The Journal of Biological Chemistry. 278: 41749-55
Malygin EG, Zinoviev VV, Evdokimov AA, et al. (2003) DNA (cytosine-N4-)- and -(adenine-N6-)-methyltransferases have different kinetic mechanisms but the same reaction route. A comparison of M.BamHI and T4 Dam. The Journal of Biological Chemistry. 278: 15713-9
Lindstrom WM, Malygin EG, Ovechkina LG, et al. (2003) Functional analysis of BamHI DNA cytosine-N4 methyltransferase. Journal of Molecular Biology. 325: 711-20
Malygin EG, Evdokimov AA, Zinoviev VV, et al. (2001) A dual role for substrate S-adenosyl-L-methionine in the methylation reaction with bacteriophage T4 Dam DNA-[N6-adenine]-methyltransferase. Nucleic Acids Research. 29: 2361-9
Malygin EG, Lindstrom WM, Schlagman SL, et al. (2000) Pre-steady state kinetics of bacteriophage T4 dam DNA-[N(6)-adenine] methyltransferase: interaction with native (GATC) or modified sites. Nucleic Acids Research. 28: 4207-11
Lindstrom WM, Flynn J, Reich NO. (2000) Reconciling structure and function in HhaI DNA cytosine-C-5 methyltransferase. The Journal of Biological Chemistry. 275: 4912-9
Allan BW, Garcia R, Maegley K, et al. (1999) DNA bending by EcoRI DNA methyltransferase accelerates base flipping but compromises specificity Journal of Biological Chemistry. 274: 19269-19275
Allan BW, Beechem JM, Lindstrom WM, et al. (1998) Direct real time observation of base flipping by the EcoRI DNA methyltransferase. The Journal of Biological Chemistry. 273: 2368-73
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