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Fa-Kuen Shieh, Ph.D.

Affiliations: 
2007 University of California, Santa Barbara, Santa Barbara, CA, United States 
Area:
Materials Chemistry, Biochemistry & Biophysics, Biomedical Sciences, Biology-Inspired Chemistry & Physics, Deivces, Assembly & Nanochemistry, Structural Chemistry, Spectroscopy & Advanced Analysis
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"Fa-Kuen Shieh"
Mean distance: 9.54
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Parents

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Norbert O. Reich grad student 2007 UC Santa Barbara
 (Mechanistic studies of C5-cytosine DNA methylation: Functional and structural analysis of catalytic residues in M.HhaI.)

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Publications

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Shieh FK, Reich NO. (2007) AdoMet-dependent methyl-transfer: Glu119 is essential for DNA C5-cytosine methyltransferase M.HhaI. Journal of Molecular Biology. 373: 1157-68
Youngblood B, Shieh FK, Buller F, et al. (2007) S-adenosyl-L-methionine-dependent methyl transfer: observable precatalytic intermediates during DNA cytosine methylation. Biochemistry. 46: 8766-75
Shieh FK, Youngblood B, Reich NO. (2006) The role of Arg165 towards base flipping, base stabilization and catalysis in M.HhaI. Journal of Molecular Biology. 362: 516-27
Youngblood B, Shieh FK, De Los Rios S, et al. (2006) Engineered extrahelical base destabilization enhances sequence discrimination of DNA methyltransferase M.HhaI. Journal of Molecular Biology. 362: 334-46
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