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Rory Curtis

Affiliations: 
Elixir Pharmaceuticals, Cambridge, MA, United States 
Area:
GAP43, glia, ion channels, regeneration, neurotrophins, GAP-43
Google:
"Rory Curtis"
Bio:

Email: rorycurtis@comcast.net ............ History: PhD, Biochemistry, Imperial College, London, UK;
Post-doc, Regeneron Pharmaceuticals, NY;
Lecturer, Bristol University, Bristol, UK;
Senior Scientist, Millennium Pharmaceuticals, MA;
Senior Director, Elixir Pharmaceuticals, MA;

Mean distance: 14.95 (cluster 11)
 		SNBCP
Cross-listing: Neurotree

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Parents

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Michael R. Hanley research assistant 1985-1987 Imperial College London
Graham P. Wilkin grad student 1985-1991 Imperial College London (Neurotree)
Peter S. DiStefano post-doc 1991-1995 Regeneron Pharmaceuticals
Ronald M. Lindsay post-doc 1991-1995 Regeneron Pharmaceuticals (Neurotree)

Children

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Scott Eliasof research scientist 2000-2001 Millennium Pharmaceuticals (Neurotree)
Tara M. D'Eon research scientist 2006-2007 Elixir Pharmaceuticals (Neurotree)
Julie Huber research scientist 2002-2008 Elixir Pharmaceuticals

Collaborators

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William A. Catterall collaborator Wahington University (Neurotree)
David E. Clapham collaborator Harvard Medical School/HHMI
Susan M. Hall collaborator Guy's Hospital, London (Neurotree)
Mats H. Holmqvist collaborator Millennium Pharmaceuticals (Neurotree)
Krisjan Jessen collaborator UCL (Neurotree)
Irwin Levitan collaborator Boston University, Brandeis University
Rhona Mirsky collaborator UCL (Neurotree)
John V. Priestley collaborator Thomas's Hospital, London (Neurotree)
Steven S. Scherer collaborator Penn (Neurotree)
Immaculada Silos-Santiago collaborator Millennium Pharmaceuticals
Barbara A. Spruce collaborator Imperial College, London (Neurotree)
Helen Stewart collaborator UCL (Neurotree)
Carlos Ibanez collaborator 1993-1995 Regeneron Pharmaceuticals (Neurotree)
David Wynick collaborator 1995-1997 University of Bristol (Neurotree)
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Publications

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Longo KA, Govek EK, Nolan A, et al. (2012) Pharmacologic inhibition of ghrelin receptor signaling is insulin sparing and promotes insulin sensitivity (Journal of Pharmacology and Experimental Therapeutics (2011) 339, (115-124)) Journal of Pharmacology and Experimental Therapeutics. 340: 810
Longo KA, Govek EK, Nolan A, et al. (2011) Pharmacologic inhibition of ghrelin receptor signaling is insulin sparing and promotes insulin sensitivity. The Journal of Pharmacology and Experimental Therapeutics. 339: 115-24
DiStefano PS, Curtis R, Geddes BJ. (2007) Insulin resistance, glycemic control and adiposity: key determinants of healthy lifespan. Current Alzheimer Research. 4: 153-7
Curtis R, O'Connor G, DiStefano PS. (2006) Aging networks in Caenorhabditis elegans: AMP-activated protein kinase (aak-2) links multiple aging and metabolism pathways. Aging Cell. 5: 119-26
Solomon JM, Pasupuleti R, Xu L, et al. (2006) Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Molecular and Cellular Biology. 26: 28-38
Napper AD, Hixon J, McDonagh T, et al. (2005) Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. Journal of Medicinal Chemistry. 48: 8045-54
McDonagh T, Hixon J, DiStefano PS, et al. (2005) Microplate filtration assay for nicotinamide release from NAD using a boronic acid resin. Methods (San Diego, Calif.). 36: 346-50
Curtis R, Geesaman BJ, DiStefano PS. (2005) Ageing and metabolism: drug discovery opportunities. Nature Reviews. Drug Discovery. 4: 569-80
Kaeberlein M, McDonagh T, Heltweg B, et al. (2005) Substrate-specific activation of sirtuins by resveratrol. The Journal of Biological Chemistry. 280: 17038-45
Apfeld J, O'Connor G, McDonagh T, et al. (2004) The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. Genes & Development. 18: 3004-9
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