John A. Latham, Ph.D.

Affiliations: 
2012 Chemistry and Chemical Biology University of New Mexico, Albuquerque, NM, United States 
Area:
Biochemistry
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"John Latham"
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Parents

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Debra Dunaway-Mariano grad student 2012 Univ. of New Mexico
 (Structure to function: Case studies of hotdog-fold superfamily thioesterases from Escherichia coli.)
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Publications

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Lien Y, Lachowicz JC, Mendauletova A, et al. (2024) Structural, Biochemical, and Bioinformatic Basis for Identifying Radical SAM Cyclopropyl Synthases. Acs Chemical Biology
Mendauletova A, Kostenko A, Lien Y, et al. (2021) How a Subfamily of Radical S-Adenosylmethionine Enzymes Became a Mainstay of Ribosomally Synthesized and Post-translationally Modified Peptide Discovery. Acs Bio & Med Chem Au. 2: 53-59
Martins AM, Latham JA, Martel PJ, et al. (2019) A two-component protease in with high activity toward the peptide precursor of the redox cofactor pyrroloquinoline quinone. The Journal of Biological Chemistry
Ayikpoe RS, Latham JA. (2019) MftD Catalyzes the Formation of a Biologically Active Redox Center in the Biosynthesis of the Ribosomally Synthesized and Post-translationally Modified Redox Cofactor, Mycofactocin. Journal of the American Chemical Society
Koehn EM, Latham JA, Armand T, et al. (2019) Discovery of Hydroxylase Activity for PqqB Provides a Missing Link in the Pyrroloquinoline Quinone Biosynthetic Pathway. Journal of the American Chemical Society
Ayikpoe R, Govindarajan V, Latham JA. (2019) Occurrence, function, and biosynthesis of mycofactocin. Applied Microbiology and Biotechnology
Ayikpoe R, Ngendahimana T, Langton M, et al. (2019) Spectroscopic and electrochemical characterization of the mycofactocin biosynthetic protein, MftC, provides insight into its redox flipping mechanism. Biochemistry
Ayikpoe R, Salazar J, Majestic B, et al. (2018) Mycofactocin Biosynthesis Proceeds through 3-Amino-5-[( p-hydroxyphenyl)methyl]-4,4-dimethyl-2-pyrrolidinone (AHDP); Direct Observation of MftE Specificity toward MftA. Biochemistry
Barr I, Stich TA, Gizzi AS, et al. (2018) X-ray and EPR Characterization of the Auxiliary Fe-S Clusters in the Radical SAM Enzyme PqqE. Biochemistry
Latham JA, Barr I, Klinman JP. (2017) At the confluence of ribosomally synthesized peptide modification and radical S-adenosylmethionine (SAM) enzymology. The Journal of Biological Chemistry
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