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Denis Drygin, Ph.D.

Affiliations: 
2002 University of Massachusetts, Amherst, Amherst, MA 
Area:
Molecular Biology, Biochemistry
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"Denis Drygin"
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R A. Zimmermann grad student 2002 U Mass Amherst
 (Studies of the complex of ribosomal protein L1 with its binding site in 23S rRNA: Modification -interference, mutagenesis and crosslinking.)

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Publications

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Drygin D, Lin A, Bliesath J, et al. (2011) Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth. Cancer Research. 71: 1418-30
Drygin D, Siddiqui-Jain A, O'Brien S, et al. (2009) Anticancer activity of CX-3543: a direct inhibitor of rRNA biogenesis. Cancer Research. 69: 7653-61
Nikulin A, Eliseikina I, Tishchenko S, et al. (2003) Structure of the L1 protuberance in the ribosome. Nature Structural Biology. 10: 104-8
Drygin D, Zimmermann RA. (2000) Magnesium ions mediate contacts between phosphoryl oxygens at positions 2122 and 2176 of the 23S rRNA and ribosomal protein L1. Rna (New York, N.Y.). 6: 1714-26
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