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Christopher P. Landowski, Ph.D.

Affiliations: 
2005 University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Pharmacy, Oncology
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"Christopher Landowski"
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Gordon L. Amidon grad student 2005 University of Michigan
 (Designing anticancer prodrugs for targeting drug transporters and activating enzymes.)

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Dahan A, Wolk O, Yang P, et al. (2014) Dipeptidyl peptidase IV as a potential target for selective prodrug activation and chemotherapeutic action in cancers. Molecular Pharmaceutics. 11: 4385-94
Foster DR, Landowski CP, Zheng X, et al. (2009) Interferon-gamma increases expression of the di/tri-peptide transporter, h-PEPT1, and dipeptide transport in cultured human intestinal monolayers. Pharmacological Research. 59: 215-20
Tsume Y, Vig BS, Sun J, et al. (2008) Enhanced absorption and growth inhibition with amino acid monoester prodrugs of floxuridine by targeting hPEPT1 transporters. Molecules (Basel, Switzerland). 13: 1441-54
Bolanz KA, Hediger MA, Landowski CP. (2008) The role of TRPV6 in breast carcinogenesis. Molecular Cancer Therapeutics. 7: 271-9
Kim HR, Park SW, Cho HJ, et al. (2007) Comparative gene expression profiles of intestinal transporters in mice, rats and humans. Pharmacological Research. 56: 224-36
Mittal S, Tsume Y, Landowski CP, et al. (2007) Proline prodrug of melphalan, prophalan-L, demonstrates high therapeutic index in a murine melanoma model. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft FüR Pharmazeutische Verfahrenstechnik E.V. 67: 752-8
Landowski CP, Suzuki Y, Hediger MA. (2007) Transporters for excitatory and neutral amino acids Handbook of Neurochemistry and Molecular Neurobiology: Neural Membranes and Transport. 305-323
Cao X, Gibbs ST, Fang L, et al. (2006) Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model. Pharmaceutical Research. 23: 1675-86
Lorenzi PL, Landowski CP, Brancale A, et al. (2006) N-methylpurine DNA glycosylase and 8-oxoguanine dna glycosylase metabolize the antiviral nucleoside 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1070-7
Landowski CP, Lorenzi PL, Song X, et al. (2006) Nucleoside ester prodrug substrate specificity of liver carboxylesterase. The Journal of Pharmacology and Experimental Therapeutics. 316: 572-80
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