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Lydia M. Gibson, Ph.D.

Affiliations: 
2009 Chemistry University of South Carolina, Columbia, SC 
Area:
Biochemistry
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Lukasz Lebioda grad student 2009 University of South Carolina
 (Structural and fluorescent characterization of ligand binding to human thymidylate synthase mutants and crystallographic studies of yeast glutaredoxin 3 thioredoxin-like domain.)

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Gibson LM, Celeste LR, Lovelace LL, et al. (2011) Structures of human thymidylate synthase R163K with dUMP, FdUMP and glutathione show asymmetric ligand binding. Acta Crystallographica. Section D, Biological Crystallography. 67: 60-6
Huang X, Gibson LM, Bell BJ, et al. (2010) Replacement of Val3 in human thymidylate synthase affects its kinetic properties and intracellular stability . Biochemistry. 49: 2475-82
Lovelace LL, Johnson SR, Gibson LM, et al. (2009) Variants of human thymidylate synthase with loop 181-197 stabilized in the inactive conformation. Protein Science : a Publication of the Protein Society. 18: 1628-36
Gibson LM, Dingra NN, Outten CE, et al. (2008) Structure of the thioredoxin-like domain of yeast glutaredoxin 3. Acta Crystallographica. Section D, Biological Crystallography. 64: 927-32
Gibson LM, Lovelace LL, Lebioda L. (2008) The R163K mutant of human thymidylate synthase is stabilized in an active conformation: structural asymmetry and reactivity of cysteine 195. Biochemistry. 47: 4636-43
Lovelace LL, Gibson LM, Lebioda L. (2007) Cooperative inhibition of human thymidylate synthase by mixtures of active site binding and allosteric inhibitors. Biochemistry. 46: 2823-30
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