James J. Truglio, Ph.D.

Affiliations: 
2004 Stony Brook University, Stony Brook, NY, United States 
Area:
Molecular Biology, General Biophysics, Biochemistry
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"James Truglio"
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Parents

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Caroline Kisker grad student 2004 SUNY Stony Brook
 (Crystallographic and biochemical studies of the nucleotide excision repair enzymes UvrB and UvrC, and the metabolically important enzyme xanthine dehydrogenase.)
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Publications

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Spagnuolo LA, Eltschkner S, Yu W, et al. (2017) Evaluating the contribution of transition state destabilization to changes in the residence time of triazole-based InhA inhibitors. Journal of the American Chemical Society
Yu W, Neckles C, Chang A, et al. (2015) A [(32)P]NAD(+)-based method to identify and quantitate long residence time enoyl-acyl carrier protein reductase inhibitors. Analytical Biochemistry. 474: 40-9
Li HJ, Li X, Liu N, et al. (2011) Mechanism of the intramolecular Claisen condensation reaction catalyzed by MenB, a crotonase superfamily member. Biochemistry. 50: 9532-44
Lu H, England K, am Ende C, et al. (2009) Slow-onset inhibition of the FabI enoyl reductase from francisella tularensis: residence time and in vivo activity. Acs Chemical Biology. 4: 221-31
Dietzel U, Kuper J, Doebbler JA, et al. (2009) Mechanism of Substrate and Inhibitor Binding of Rhodobacter capsulatus Xanthine Dehydrogenase. The Journal of Biological Chemistry. 284: 8768-76
Wolski SC, Kuper J, Hänzelmann P, et al. (2008) Crystal structure of the FeS cluster-containing nucleotide excision repair helicase XPD. Plos Biology. 6: e149
Respicio L, Nair PA, Huang Q, et al. (2008) Characterizing septum inhibition in Mycobacterium tuberculosis for novel drug discovery. Tuberculosis (Edinburgh, Scotland). 88: 420-9
Karakas E, Truglio JJ, Croteau D, et al. (2007) Structure of the C-terminal half of UvrC reveals an RNase H endonuclease domain with an Argonaute-like catalytic triad. The Embo Journal. 26: 613-22
Kolappan S, Zwahlen J, Zhou R, et al. (2007) Lysine 190 is the catalytic base in MenF, the menaquinone-specific isochorismate synthase from Escherichia coli: implications for an enzyme family. Biochemistry. 46: 946-53
Sullivan TJ, Truglio JJ, Boyne ME, et al. (2006) High affinity InhA inhibitors with activity against drug-resistant strains of Mycobacterium tuberculosis. Acs Chemical Biology. 1: 43-53
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