Travis T. Denton, Ph.D.
Affiliations: | 2002 | University of Montana, Missoula, MT |
Area:
Organic Chemistry, Pharmaceutical Chemistry, BiochemistryGoogle:
"Travis Denton"Mean distance: (not calculated yet)
Parents
Sign in to add mentorCharles M. Thompson | grad student | 2002 | Univ. Montana | |
(Synthesis of conformationally constrained glutamate analogues and their preliminary evaluation as glutamate transport inhibitors.) |
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Publications
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Shen D, Kruger L, Deatherage T, et al. (2020) Synthesis of α-Ketoglutaramic acid. Analytical Biochemistry. 113862 |
Banerjee K, Munshi S, Xu H, et al. (2016) Mild mitochondrial metabolic deficits by α-ketoglutarate dehydrogenase inhibition cause prominent changes in intracellular autophagic signaling: Potential role in the pathobiology of Alzheimer's disease. Neurochemistry International |
Gibson GE, Xu H, Chen HL, et al. (2015) Alpha-ketoglutarate dehydrogenase complex-dependent succinylation of proteins in neurons and neuronal cell lines. Journal of Neurochemistry. 134: 86-96 |
Hensley K, Denton TT. (2015) Alternative functions of the brain transsulfuration pathway represent an underappreciated aspect of brain redox biochemistry with significant potential for therapeutic engagement. Free Radical Biology & Medicine. 78: 123-34 |
Bobango J, Denton TT, Talley TT. (2015) A survey of high resolution AChBP X-ray structures reveals details of tertiary and quaternary movements of the protein, both real and imagined, upon ligand binding Biochemical Pharmacology. 97: 628 |
Yano JK, Denton TT, Cerny MA, et al. (2006) Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization. Journal of Medicinal Chemistry. 49: 6987-7001 |
Santos SS, Gibson GE, Cooper AJ, et al. (2006) Inhibitors of the alpha-ketoglutarate dehydrogenase complex alter [1-13C]glucose and [U-13C]glutamate metabolism in cerebellar granule neurons. Journal of Neuroscience Research. 83: 450-8 |
Bunik VI, Denton TT, Xu H, et al. (2005) Phosphonate analogues of alpha-ketoglutarate inhibit the activity of the alpha-ketoglutarate dehydrogenase complex isolated from brain and in cultured cells. Biochemistry. 44: 10552-61 |
Denton TT, Zhang X, Cashman JR. (2005) 5-substituted, 6-substituted, and unsubstituted 3-heteroaromatic pyridine analogues of nicotine as selective inhibitors of cytochrome P-450 2A6. Journal of Medicinal Chemistry. 48: 224-39 |
Denton T, Seib T, Bridges R, et al. (2002) Synthesis and preliminary evaluation of trans-3,4-conformationally-restricted glutamate and pyroglutamate analogues as novel EAAT2 inhibitors. Bioorganic & Medicinal Chemistry Letters. 12: 3209-13 |