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James Mahaney

Affiliations: 
West Virginia University, Morgantown, WV, United States 
Area:
Biochemistry
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Jason S. Southall grad student 2002 West Virginia University
Jason R. Waggoner grad student 2004 West Virginia University

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Publications

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Keceli G, Majumdar A, Thorpe CN, et al. (2019) Nitroxyl (HNO) targets phospholamban cysteines 41 and 46 to enhance cardiac function. The Journal of General Physiology
Keceli G, Majumdar A, Thorpe CN, et al. (2017) HNO Modifies Cysteines 41 and 46 in the Transmembrane Domain of Phospholamban Increasing SERCA2a Activity Free Radical Biology and Medicine. 112: 114-115
Keceli G, Majumdar A, Thorpe CN, et al. (2016) Investigation of HNO-Derived Modifications on Phospholamban Biophysical Journal. 110: 541a
Sivakumaran V, Stanley BA, Tocchetti CG, et al. (2013) HNO enhances SERCA2a activity and cardiomyocyte function by promoting redox-dependent phospholamban oligomerization. Antioxidants & Redox Signaling. 19: 1185-97
Sivakumaran V, Thorpe C, Keceli G, et al. (2010) HNO Uncouples PLN from SERCA2a Enhancing Pump Activity Biophysical Journal. 98: 170a
Mahaney JE, Thomas DD, Keceli G, et al. (2010) Phospholabman Regulation of SERCA2a Kinetics, as Modulated by Nitroxyl Biophysical Journal. 98: 763a
Paolocci N, Tocchetti CG, Mahaney JE, et al. (2010) Nitroxyl and “Forbidden Disulfides”: Phospholamban Cysteines are Targeted to Enhance SERCA2a Activity Biophysical Journal. 98: 763a
Tocchetti CG, Froehlich JP, Mahaney JE, et al. (2009) Nitroxyl (HNO) Modifies Cysteine Residues in Phospholamban to Increase Myocyte Ca2+-Cycling and Contractility Biophysical Journal. 96: 515a-516a
Thorpe C, De Arras L, Toscano JP, et al. (2009) The Role of Phospholamban Cysteines in the Activation of the Cardiac Sarcoplasmic Reticulum Calcium Pump by Nitroxyl Biophysical Journal. 96: 326a
Froehlich JP, Mahaney JE, Keceli G, et al. (2008) Phospholamban thiols play a central role in activation of the cardiac muscle sarcoplasmic reticulum calcium pump by nitroxyl. Biochemistry. 47: 13150-2
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